紫花前胡苷

• 常用名: 紫花前胡苷
• 英文名: Nodakenin
• CAS号: 495-31-8
• 分子量: 408.399
• 密度: 1.5±0.1 g/cm3
• 沸点: 635.4±55.0 °C at 760 mmHg
• 分子式: C₂₀H₂₄O₉
• 熔点: melting at 216°
• 闪点: 225.4±25.0 °C

紫花前胡苷用途

Nodakenin 是 Peucedanum decursivum Maxim 根中的主要香豆素苷。Nodakenin 抑制乙酰胆碱酯酶 (AChE) 活性,IC50 为 84.7 μM。

紫花前胡苷名称

• 中文名: 紫花前胡苷
• 英文名: Nodakenin
• 中文别名: 含紫花前胡甙

紫花前胡苷生物活性

• 描述: Nodakenin 是 Peucedanum decursivum Maxim 根中的主要香豆素苷。Nodakenin 抑制乙酰胆碱酯酶 (AChE) 活性,IC50 为 84.7 μM。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 神经信号通路 >> 疼痛
• 参考文献:

  [1]. Kim DH, et al. Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice. Life Sci. 2007 May 1;80(21):1944-50.

  [2]. Xiong Y, et al. The effects of nodakenin on airway inflammation, hyper-responsiveness and remodeling in a murine model of allergic asthma. Immunopharmacol Immunotoxicol. 2014 Oct;36(5):341-8.

紫花前胡苷物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 635.4±55.0 °C at 760 mmHg
• 熔点: melting at 216°
• 分子式: C₂₀H₂₄O₉
• 分子量: 408.399
• 闪点: 225.4±25.0 °C
• 精确质量: 408.142029
• PSA: 138.82000
• LogP: -0.66
• InChIKey: HXCGUCZXPFBNRD-DNLMCPORSA-N
• SMILES: CC(C)(OC1OC(CO)C(O)C(O)C1O)C1Cc2cc3ccc(=O)oc3cc2O1
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.651

紫花前胡苷安全信息

• 安全声明 (欧洲): 24/25
• 海关编码: 29389090

紫花前胡苷靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

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紫花前胡苷英文别名

• 2-(7-Oxo-2,3-dihydro-7H-furo[3,2-g]chromen-3-yl)-2-propanyl β-D-glucopyranoside
• 2-(7-Oxo-2,3-dihydro-7H-furo[3,2-g]chromen-3-yl)propan-2-yl β-D-glucopyranoside
• 2-[1-(b-D-Glucopyranosyloxy)-1-methylethyl]-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-7-one
• Nodakenetin Glucoside