Org 25543 hydrochloride

• 常用名: Org 25543 hydrochloride
• 英文名: Org 25543 hydrochloride
• CAS号: 495076-64-7
• 分子量: 448.98
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₃₃ClN₂O₄
• 熔点: N/A
• 闪点: N/A

Org 25543 hydrochloride用途

Org 25543 h ydrochloride是一种选择性且不可逆的 GlyT2 抑制剂 (IC50: 16 nM)。Org 25543 hydrochloride 具有镇痛作用。Org 25543 hydrochloride 可改善小鼠部分坐骨神经结扎损伤后的机械性异常性疼痛。

Org 25543 hydrochloride名称

• 英文名: 4-(Benzyloxy)-N-{[1-(dimethylamino)cyclopentyl]methyl}-3,5-dimethoxybenzamide hydrochloride (1:1)

Org 25543 hydrochloride生物活性

• 描述: Org 25543 h ydrochloride是一种选择性且不可逆的 GlyT2 抑制剂 (IC50: 16 nM)。Org 25543 hydrochloride 具有镇痛作用。Org 25543 hydrochloride 可改善小鼠部分坐骨神经结扎损伤后的机械性异常性疼痛。
• 相关类别:
  信号通路 >> 跨膜转运 >> GLYT
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> GLYT
• 参考文献:

  [1]. Caulfield WL, et al. The first potent and selective inhibitors of the glycine transporter type 2. J Med Chem. 2001 Aug 16;44(17):2679-82.

  [2]. Morita K, et al. Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J Pharmacol Exp Ther. 2008 Aug;326(2):633-45.

  [3]. Mohammadzadeh A, et al. Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model. Int J Mol Sci. 2021 Mar 1;22(5):2479.

Org 25543 hydrochloride物理化学性质

• 分子式: C₂₄H₃₃ClN₂O₄
• 分子量: 448.98
• 精确质量: 448.212891
• InChIKey: NIPQJILJYQVZJR-UHFFFAOYSA-N
• SMILES: COc1cc(C(=O)NCC2(N(C)C)CCCC2)cc(OC)c1OCc1ccccc1.Cl

Org 25543 hydrochloride英文别名

• 4-(Benzyloxy)-N-{[1-(dimethylamino)cyclopentyl]methyl}-3,5-dimethoxybenzamide hydrochloride (1:1)
• Benzamide, N-[[1-(dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)-, hydrochloride (1:1)
• MFCD23701926