β-Eleostearic acid

• 常用名: β-Eleostearic acid
• 英文名: β-Eleostearic acid
• CAS号: 506-23-0
• 分子量: 278.430
• 密度: 0.9±0.1 g/cm3
• 沸点: 390.6±11.0 °C at 760 mmHg
• 分子式: C₁₈H₃₀O₂
• 熔点: N/A
• 闪点: 287.4±14.4 °C

β-Eleostearic acid用途

α-异硬脂酸(顺式异硬脂酸),一种共轭亚麻酸,是一种凋亡诱导剂。α-Eleostaric酸也是一种铁下垂诱导剂。α-榄香酸具有抗氧化和抗肿瘤活性[1][2][3]。

β-Eleostearic acid名称

• 英文名: (E,Z,E)-octadeca-9,11,13-trienoic acid

β-Eleostearic acid生物活性

• 描述: α-异硬脂酸(顺式异硬脂酸),一种共轭亚麻酸,是一种凋亡诱导剂。α-Eleostaric酸也是一种铁下垂诱导剂。α-榄香酸具有抗氧化和抗肿瘤活性[1][2][3]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 细胞凋亡 >> Ferroptosis
  研究领域 >> 代谢疾病
• 体外研究: α-异硬脂酸(0-40μM；24小时)抑制一些癌细胞系和成纤维细胞系的生长,包括 HL60型细胞和 第29页细胞[1]。 α-异硬脂酸(20μM；6小时)在 HL60型细胞中诱导典型的细胞凋亡现象：细胞和核碎裂,以及核小体 脱氧核糖核酸碎裂[1]。 α-异硬脂酸(0.01-100μM；72小时)触发 MDA-MB-231型细胞死亡,这种死亡被 Fer-1、去甲罗胺和维生素 E抑制[1]。
• 体内研究: α-异硬脂酸(总脂质的0.5%；口服)抑制 亚砷酸钠诱导的体内氧化应激：逆转抗氧化酶活性和降低脂质过氧化水平[2]。 在侵袭性 TNBC公司原位异种移植模型中,给小鼠口服天然富含 α-异硬脂酸的桐油可限制肿瘤生长和转移[3]。
• 参考文献:

  [1]. Kobori M, et, al. Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd. J Agric Food Chem. 2008 Nov 26;56(22):10515-20.

  [2]. Saha SS, et, al. Comparative study of antioxidant activity of alpha-eleostearic acid and punicic acid against oxidative stress generated by sodium arsenite. Food Chem Toxicol. 2009 Oct;47(10):2551-6.

  [3]. Beatty A, et, al. Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1. Nat Commun. 2021 Apr 14;12(1):2244.

β-Eleostearic acid物理化学性质

• 密度: 0.9±0.1 g/cm3
• 沸点: 390.6±11.0 °C at 760 mmHg
• 分子式: C₁₈H₃₀O₂
• 分子量: 278.430
• 闪点: 287.4±14.4 °C
• 精确质量: 278.224579
• PSA: 37.30000
• LogP: 6.66
• InChIKey: CUXYLFPMQMFGPL-WPOADVJFSA-N
• SMILES: CCCCC=CC=CC=CCCCCCCCC(=O)O
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.491

β-Eleostearic acid靶点实验

查看更多实验

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

共5条，当前第1页，共1页

1

β-Eleostearic acid英文别名

• 9Z,11E,13E-Octadecatrienoic Acid
• (9E,11E,13E)-Octadeca-9,11,13-trienoic acid
• (E,E,E)-9,11,13-octadecatrienoic acid
• 9(Z),11(E),13(E)-OCTADECATRIENOIC ACID
• α-Eleostearic acid
• (9Z,11E,13E)-9,11,13-Octadecatrienoic acid
• (9Z,11E,13E)-octadeca-9,11,13-trienoic acid
• cis-9, trans-11, trans-13-octadecatrienoic acid
• 9-cis,11-trans,13-trans-octadecatrienoic acid
• (9E,11E,13E)-9,11,13-Octadecatrienoic acid
• (E,E,E)-octadeca-9,11,13-trienoic acid
• β-Eleostearic acid
• 9E,11E,13E-octadecatrienoic acid
• a-Eleostearic Acid
• (9Z,11E,13E)-Octadecatrienoic acid
• trans-9, trans-11, trans-13-octadecatrienoic acid