重楼皂苷D

• 常用名: 重楼皂苷D
• 英文名: Polyphyllin D
• CAS号: 50773-41-6
• 分子量: 855.017
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₄₄H₇₀O₁₆
• 熔点: N/A
• 闪点: N/A

重楼皂苷D用途

Polyphyllin I 是一种从 Paris polyphylla 中提取的生物活性成分,具有很强的抗肿瘤活性。Polyphyllin I 是JNK 信号通路的激活剂,也是 PDK1/Akt/mTOR 信号传导的抑制剂。Polyphyllin I 诱导自噬,G2/M 期阻滞和细胞凋亡。

重楼皂苷D名称

• 中文名: 重楼皂苷I
• 英文名: Polyphyllin I
• 中文别名: 重楼皂甙I | 重楼皂甙A.

重楼皂苷D生物活性

• 描述: Polyphyllin I 是一种从 Paris polyphylla 中提取的生物活性成分,具有很强的抗肿瘤活性。Polyphyllin I 是JNK 信号通路的激活剂,也是 PDK1/Akt/mTOR 信号传导的抑制剂。Polyphyllin I 诱导自噬,G2/M 期阻滞和细胞凋亡。
• 相关类别:
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> mTOR
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PDK-1
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 自噬 >> 自噬
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AKT
  信号通路 >> MAPK/ERK信号通路 >> JNK
• 靶点实验:

  JNK signaling[2] PDK1/Akt/mTOR signaling[3]

• 参考文献:

  [1]. Kong M, et al. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai). 2010 Nov;42(11):827-33.

  [2]. Liu J, et al. Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2017 Jun 1;49(6):479-486.

  [3]. He J, et al. Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 2019 Sep;117:109189.

重楼皂苷D物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₄₄H₇₀O₁₆
• 分子量: 855.017
• 精确质量: 854.466370
• PSA: 235.68000
• LogP: 7.12
• InChIKey: LRRDDWMXYOSKIC-GJAFGZJPSA-N
• SMILES: CC1CCC2(OC1)OC1CC3C4CC=C5CC(OC6OC(CO)C(OC7OC(CO)C(O)C7O)C(O)C6OC6OC(C)C(O)C(O)C6O)CCC5(C)C4CCC3(C)C1C2C
• 折射率: 1.618
• 储存条件: 室温

重楼皂苷D安全信息

• 海关编码: 29389090

重楼皂苷D靶点实验

查看更多实验

实验名称：Induction of apoptosis in human HepG2 cells at 1 uM after 24 hrs by propidium iodide ... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL3859387

实验名称：Induction of chromatin compaction in human HepG2 cells at 1 uM after 24 hrs by Hoechs... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL3859383

实验名称：Cell cycle arrest in human HepG2 cells assessed as accumulation at G1 phase at 1 uM a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3859384

实验名称：Cell cycle arrest in human HepG2 cells assessed as accumulation at S phase at 1 uM af... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3859385

实验名称：Cell cycle arrest in human HepG2 cells assessed as accumulation at G2 phase at 1 uM a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3859386

实验名称：Induction of apoptosis in human HepG2 cells at 1 uM after 24 hrs by propidium iodide ... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL3859395

实验名称：Increase in p21 mRNA level in human HepG2 cells at 1 uM incubated for 24 hrs by RT-PC... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL3859398

实验名称：Cell cycle arrest in human HepG2 cells assessed as accumulation at G1 phase at 1 uM a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3859392

实验名称：Cell cycle arrest in human HepG2 cells assessed as accumulation at G2 phase at 1 uM a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3859393

实验名称：Cell cycle arrest in human HepG2 cells assessed as accumulation at S phase at 1 uM af... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3859394

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重楼皂苷D英文别名

• (3β,25R)-Spirost-5-en-3-yl α-L-arabinofuranosyl-(1->4)-[6-deoxy-α-L-mannopyranosyl-(1->2)]-β-D-glucopyranoside
• Chonglou saponin I
• Polyphyllin A
• Polyphyllin Ⅰ