CJ 033466

• 常用名: CJ 033466
• 英文名: CJ 033466
• CAS号: 519148-48-2
• 分子量: 377.91200
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₈ClN₅O
• 熔点: N/A
• 闪点: N/A

CJ 033466用途

CJ033466是一种新型的选择性5-HT4受体部分激动剂,EC50为9 nM,具有促胃动力作用[1]。

CJ 033466名称

• 英文名: 5-amino-6-chloro-2-methyl-N-[[1-(2-methylpropyl)piperidin-4-yl]methyl]imidazo[1,2-a]pyridine-8-carboxamide

CJ 033466生物活性

• 描述: CJ033466是一种新型的选择性5-HT4受体部分激动剂,EC50为9 nM,具有促胃动力作用[1]。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点实验:

  5-HT4 Receptor:9 nM (EC50)

• 参考文献:

  [1]. Tadayoshi Mikami, et al. 5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-alpha]pyridine-8-carboxamide (CJ-033,466), a novel and selective 5-hydroxytryptamine4 receptor partial agonist: pharmacological profile in vitro and gastroprokinetic effect in conscious dogs. J Pharmacol Exp Ther. 2008 Apr;325(1):190-9.

CJ 033466物理化学性质

• 分子式: C₁₉H₂₈ClN₅O
• 分子量: 377.91200
• 精确质量: 377.19800
• PSA: 75.66000
• LogP: 3.88610
• InChIKey: ISKHMDNIWXPUGR-UHFFFAOYSA-N
• SMILES: Cc1cn2c(N)c(Cl)cc(C(=O)NCC3CCN(CC(C)C)CC3)c2n1

CJ 033466靶点实验

查看更多实验

实验名称：NCATS Kinetic Aqueous Solubility Profiling 来源：NCGC 靶标：N/A External Id：ADME-solubility1

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：NCATS Parallel Artificial Membrane Permeability Assay (PAMPA) Profiling 来源：NCGC 靶标：N/A External Id：ADME-PAMPA1

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

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CJ 033466英文别名

• UNII-9KUW8W70PJ
• CJ-033,466
• PG-9 maleate