樱桃甙； 洋李甙

• 常用名: 樱桃甙； 洋李甙
• 英文名: Prunin
• CAS号: 529-55-5
• 分子量: 434.393
• 密度: 1.6±0.1 g/cm3
• 沸点: 802.4±65.0 °C at 760 mmHg
• 分子式: C₂₁H₂₂O₁₀
• 熔点: 222-224ºC
• 闪点: 284.6±27.8 °C
• 符号: GHS09
• 信号词: Warning

樱桃甙； 洋李甙用途

Prunin 是有效的人肠道病毒 A71 (HEVA71) 抑制剂。Prunin 对蛋白酪氨酸磷酸酶 1B (PTP1B) 有较强的抑制作用,IC50 值为 5.5 μM。

樱桃甙； 洋李甙名称

• 中文名: 柚(苷)配基-7-O-葡糖苷
• 英文名: naringenin 7-O-β-D-glucoside
• 中文别名: 樱桃甙 | 樱桃苷 | 樱桃甙,洋李甙

樱桃甙； 洋李甙生物活性

• 描述: Prunin 是有效的人肠道病毒 A71 (HEVA71) 抑制剂。Prunin 对蛋白酪氨酸磷酸酶 1B (PTP1B) 有较强的抑制作用,IC50 值为 5.5 μM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶
  研究领域 >> 感染
  研究领域 >> 代谢疾病
• 体外研究: Prunin通过降低胰岛素抵抗HepG2细胞PTP1B的表达水平,对ONOO介导的酪氨酸硝化和葡萄糖摄取具有剂量依赖性抑制作用。Prunin对α-葡萄糖苷酶有明显的抑制作用,IC50为317±2.12μM[2]。
• 参考文献:

  [1]. Gunaseelan S, et al. Prunin suppresses viral IRES activity and is a potential candidate for treating enterovirus A71 infection. Sci Transl Med. 2019 Oct 30;11(516). pii: eaar5759.

  [2]. Jung HA, et al. Prunin is a highly potent flavonoid from Prunus davidiana stems that inhibits protein tyrosine phosphatase 1B and stimulates glucose uptake in insulin-resistant HepG2 cells. Arch Pharm Res. 2017 Jan;40(1):37-48.

樱桃甙； 洋李甙物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 802.4±65.0 °C at 760 mmHg
• 熔点: 222-224ºC
• 分子式: C₂₁H₂₂O₁₀
• 分子量: 434.393
• 闪点: 284.6±27.8 °C
• 精确质量: 434.121307
• PSA: 166.14000
• LogP: 0.82
• InChIKey: DLIKSSGEMUFQOK-UHFFFAOYSA-N
• SMILES: O=C1CC(c2ccc(O)cc2)Oc2cc(OC3OC(CO)C(O)C(O)C3O)cc(O)c21
• 蒸汽压: 0.0±3.0 mmHg at 25°C
• 折射率: 1.691
• 储存条件: ?20°C

樱桃甙； 洋李甙安全信息

• 符号: GHS09
• 信号词: Warning
• 危害声明: H410
• 警示性声明: P273-P501
• 危害码 (欧洲): N
• 风险声明 (欧洲): 22
• 安全声明 (欧洲): 22-45
• 危险品运输编码: UN 3077 9 / PGIII

樱桃甙； 洋李甙靶点实验

查看更多实验

实验名称：Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins 来源：ChEMBL 靶标：N/A External Id：CHEMBL1103343

实验名称：Inhibition of Influenza A virus (A/Hong Kong/1/1968(H3N2)) neuraminidase by chemilumi... 来源：ChEMBL 靶标：Neuraminidase External Id：CHEMBL3131472

实验名称：Inhibition of oseltamivir-resistant Influenza A virus H1N1 B/55/08 neuraminidase by c... 来源：ChEMBL 靶标：Neuraminidase External Id：CHEMBL3131473

实验名称：Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase by chemilu... 来源：ChEMBL 靶标：Neuraminidase External Id：CHEMBL3131474

实验名称：Inhibition of Influenza A virus J/8178/09 neuraminidase by chemiluminescence based as... 来源：ChEMBL 靶标：Neuraminidase External Id：CHEMBL3131475

实验名称：Inhibition of human OATP2B1 expressed in Flp-In-CHO cells assessed as inhibition of O... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 2B1 External Id：CHEMBL5260630

实验名称：Anti-diabetic activity in insulin-resistant human HepG2 cells assessed as increase in... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4030285

实验名称：Inhibition of human OATP2B1 expressed in Flp-In-CHO cells assessed as inhibition of O... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 2B1 External Id：CHEMBL5260629

实验名称：Anti-diabetic activity in insulin-resistant human HepG2 cells assessed as increase in... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4030283

实验名称：Inhibition of human OATP2B1 expressed in Flp-In-CHO cells assessed as inhibition of O... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 2B1 External Id：CHEMBL5260631

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樱桃甙； 洋李甙英文别名

• 5-Hydroxy-2-(4-hydroxyphényl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromén-4-one
• 4',5-DIHYDROXY-7-GLUCOSYLOXYFLAVANONE
• 5-Hydroxy-2-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromen-4-on
• 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl-β-D-glucopyranoside
• naringenin 7-O-beta-D-glucoside
• 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl β-D-glucopyranoside
• NARINGENIN-7-O-GLUCOSIDE
• 5-Hydroxy-2-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromen-4-one
• Naringenin-7-glucoside
• PRUNIN