PIT-1

更新时间：2024-01-05 17:49:20

PIT-1结构式	常用名	PIT-1	英文名	PIT-1
	CAS号	53501-41-0	分子量	351.765
	密度	1.6±0.1 g/cm3	沸点	N/A
	分子式	C₁₄H₁₀ClN₃O₄S	熔点	N/A
	MSDS	美版	闪点	N/A
	符号	GHS07, GHS09	信号词	Warning

PIT-1用途

PIT-1是一种选择性PIP3(磷脂酰肌醇3,4,5-三磷酸)拮抗剂。PIT-1通过抑制PIP3依赖的PI3K/Akt信号传导抑制癌细胞存活并诱导凋亡。PIT-1在体内具有抗肿瘤活性[1]。

英文名	N-[(3-chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide
英文别名	更多

描述	PIT-1是一种选择性PIP3(磷脂酰肌醇3,4,5-三磷酸)拮抗剂。PIT-1通过抑制PIP3依赖的PI3K/Akt信号传导抑制癌细胞存活并诱导凋亡。PIT-1在体内具有抗肿瘤活性[1]。
相关类别	研究领域 >> 癌症信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K
参考文献	[1]. Miao B, et al. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31.

密度	1.6±0.1 g/cm3
分子式	C₁₄H₁₀ClN₃O₄S
分子量	351.765
精确质量	351.008057
PSA	139.27000
LogP	4.28
折射率	1.747
储存条件	-20°C，密闭，干燥

符号	GHS07, GHS09
信号词	Warning
危害声明	H302-H400
警示性声明	P273
危险品运输编码	UN 3077 9 / PGIII

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.

Proc. Natl. Acad. Sci. U. S. A. 107(46) , 20126-31, (2010)

The PI3-kinase (PI3K) pathway regulates many cellular processes, especially cell metabolism, cell survival, and apoptosis. Phosphatidylinositol-3,4,5-trisphosphate (PIP3), the product of PI3K activity...

Inhibition of cell migration by PITENINs: the role of ARF6.

Oncogene 31(39) , 4317-32, (2012)

We have reported previously the development of small-molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including activ...

Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-benzamide

PIT-1

Impentamine dihydrobromide

N-[(3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide