MMP-13 Inhibitor

• 常用名: MMP-13 Inhibitor
• 英文名: DB04760
• CAS号: 544678-85-5
• 分子量: 410.41700
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₀F₂N₄O₂
• 熔点: N/A
• 闪点: N/A

MMP-13 Inhibitor用途

DB04760 (compound 4) 是一种有效的,高选择性,非锌螯合的 MMP-13 抑制剂,IC50 为 8 nM。DB04760 显着降低紫杉醇的神经毒性并具有抗癌活性。

MMP-13 Inhibitor名称

• 中文名: N4,N6-双(4-氟-3-甲基苄基)嘧啶-4,6-二甲酰胺
• 英文名: pyrimidine-4,6-dicarboxylic acid bis-(4-fluoro-3-methyl-benzylamide)

MMP-13 Inhibitor生物活性

• 描述: DB04760 (compound 4) 是一种有效的,高选择性,非锌螯合的 MMP-13 抑制剂,IC50 为 8 nM。DB04760 显着降低紫杉醇的神经毒性并具有抗癌活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> MMP
  研究领域 >> 神经疾病
• 靶点实验:

  MMP-13:8 nM (IC50)

• 参考文献:

  [1]. Engel CK, et al. Structural basis for the highly selective inhibition of MMP-13. Chem Biol. 2005 Feb;12(2):181-9.

  [2]. Thomas S. Lisse, et al. Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15): E2189–E2198.

MMP-13 Inhibitor物理化学性质

• 分子式: C₂₂H₂₀F₂N₄O₂
• 分子量: 410.41700
• 精确质量: 410.15500
• PSA: 83.98000
• LogP: 4.01340
• InChIKey: PYFRREJCFXFNRR-UHFFFAOYSA-N
• SMILES: Cc1cc(CNC(=O)c2cc(C(=O)NCc3ccc(F)c(C)c3)ncn2)ccc1F
• 外观性状: 固体
• 储存条件: 2-8°C，密封，干燥

MMP-13 Inhibitor靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Inhibition of recombinant human BACE1 using SEVNLDAEFRKKRR substrate at up to 5 uM af... 来源：ChEMBL 靶标：Beta-secretase 1 External Id：CHEMBL3387110

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Inhibition of recombinant human caspase 1 using WEHDGPKR substrate at up to 5 uM afte... 来源：ChEMBL 靶标：Caspase-1 External Id：CHEMBL3387112

实验名称：Inhibition of recombinant human cathepsin D using EVNLDAEFRK substrate at up to 5 uM ... 来源：ChEMBL 靶标：Cathepsin D External Id：CHEMBL3387111

实验名称：Inhibition of recombinant human caspase 3 using DEVDAA substrate at up to 5 uM after ... 来源：ChEMBL 靶标：Caspase-3 External Id：CHEMBL3387747

实验名称：Inhibition of recombinant human caspase 2 using DEVDAA substrate at up to 5 uM after ... 来源：ChEMBL 靶标：Caspase-2 External Id：CHEMBL3387746

实验名称：Non-competitive inhibition of full-length recombinant human MMP-13 assessed as fTHP-1... 来源：ChEMBL 靶标：Collagenase 3 External Id：CHEMBL3387084

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MMP-13 Inhibitor英文别名

• MMP-13 INHIBITOR
• N4,N6-Bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide