BHPI

• 常用名: BHPI
• 英文名: BHPI
• CAS号: 56632-39-4
• 分子量: 331.36500
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₁₇NO₃
• 熔点: N/A
• 闪点: N/A

BHPI用途

BHPI是核内受体ER_alpha_抑制剂,可抑制癌细胞蛋白合成和活化未折叠蛋白反应(UPR)。

BHPI名称

• 中文名: BHPI
• 英文名: 3,3-bis(4-hydroxyphenyl)-7-methyl-1H-indol-2-one

BHPI生物活性

• 描述: BHPI是核内受体ER_alpha_抑制剂,可抑制癌细胞蛋白合成和活化未折叠蛋白反应(UPR)。
• 相关类别:
  信号通路 >> 其他 >> 雌激素受体/ERR
  研究领域 >> 癌症
• 参考文献:

  [1]. Andruska ND, et al. Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4737-42.

BHPI物理化学性质

• 分子式: C₂₁H₁₇NO₃
• 分子量: 331.36500
• 精确质量: 331.12100
• PSA: 73.05000
• LogP: 3.77780
• InChIKey: FABLAHMQSQFDHR-UHFFFAOYSA-N
• SMILES: Cc1cccc2c1NC(=O)C2(c1ccc(O)cc1)c1ccc(O)cc1
• 储存条件: 2-8℃

BHPI靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Confirmatory qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinas... 来源：NCGC External Id：IP6K1-f1-cherrypicks

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

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BHPI英文别名

• HMS2153B10
• 7-methyl-oxyphenisatine
• BHPI