MK-2295

• 常用名: MK-2295
• 英文名: MK-2295
• CAS号: 573678-04-3
• 分子量: 434.34
• 密度: 1.440±0.06 g/cm3(Predicted)
• 沸点: 500.9±50.0 °C(Predicted)
• 分子式: C₂₁H₁₂F₆N₄
• 熔点: N/A
• 闪点: N/A

MK-2295用途

MK-2295(NGD-8243)是TRPV1拮抗剂。MK-2295是一种镇痛剂,可用于疼痛研究[1][2]。

MK-2295名称

• 英文名: N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine

MK-2295生物活性

• 描述: MK-2295(NGD-8243)是TRPV1拮抗剂。MK-2295是一种镇痛剂,可用于疼痛研究[1][2]。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 炎症/免疫
• 靶点实验:

  TRPV1

• 参考文献:

  [1]. Gunthorpe MJ, et al. Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway. Drug Discov Today. 2009 Jan;14(1-2):56-67.

  [2]. Arthur Gomtsyan, et al. Chapter 8 - Clinical and Preclinical Experience with TRPV1 Antagonists as Potential Analgesic Agents. TRP Channels as Therapeutic Targets. From Basic Science to Clinical Use. 2015, Pages 129-144.

MK-2295物理化学性质

• 密度: 1.440±0.06 g/cm3(Predicted)
• 沸点: 500.9±50.0 °C(Predicted)
• 分子式: C₂₁H₁₂F₆N₄
• 分子量: 434.34
• InChIKey: VTANGSDRFFLTSQ-UHFFFAOYSA-N
• SMILES: FC(F)(F)c1ccc(Nc2ncnc3cc(-c4ncccc4C(F)(F)F)ccc23)cc1

MK-2295靶点实验

查看更多实验

实验名称：Inhibition of human TRPV1 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL1113609

实验名称：Solubility in 0.1 N HCL after 4 hrs by HPLC/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL1113608

实验名称：Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as ... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL1113607

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Volume of distribution in rat at 2.7 mg/kg, iv and 2 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1114391

实验名称：Clearance in rat at 2.7 mg/kg, iv and 2 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1114390

实验名称：Half life in rat at 2.7 mg/kg, iv and 2 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1114389

实验名称：Tmax in rat at 2.7 mg/kg, iv and 2 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1114388

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