异卡波肼

• 常用名: 异卡波肼
• 英文名: Isocarboxazid
• CAS号: 59-63-2
• 分子量: 231.251
• 密度: 1.2±0.1 g/cm3
• 沸点: 394.5±42.0 °C at 760 mmHg
• 分子式: C₁₂H₁₃N₃O₂
• 熔点: 98-100ºC
• 闪点: 192.4±27.9 °C
• 符号: GHS06
• 信号词: Danger

异卡波肼用途

Isocarboxazid 是一种非选择性的、不可逆的单胺氧化酶 monoamine oxidase 抑制剂,其在大鼠大脑中测得的 IC50 值为4.8 μM。

异卡波肼名称

• 中文名: 异卡波肼
• 英文名: N'-benzyl-5-methyl-1,2-oxazole-3-carbohydrazide
• 中文别名: 异恶唑酰肼

异卡波肼生物活性

• 描述: Isocarboxazid 是一种非选择性的、不可逆的单胺氧化酶 monoamine oxidase 抑制剂,其在大鼠大脑中测得的 IC50 值为4.8 μM。
• 相关类别:
  信号通路 >> 神经信号通路 >> 单胺氧化酶
  研究领域 >> 神经疾病
• 靶点实验:

  IC50: 4.8 μM (rat brain monoamine oxidase)[1].

• 体内研究: 在小鼠中预处理Isocarboxazid(1,3 mg/kg,腹膜内注射,60分钟)显示5-HTP后15和30分钟时头部抽搐的数量显着增加[2]。与单独使用5-HTP的小鼠相比,小鼠中的Isocarboxazid(1,3 mg/kg,ip,60 min)处理与5-HTP一起施用导致43％的5-HT浓度增加和22％的5-HIAA降低[2]。动物模型：12只雄性小鼠dd株(20-25g)[2]剂量：0,0.3,1,3mg/kg给药：腹腔注射60分钟,静脉注射5-HTP结果：头部抽搐数量5-HTP增加后15和30分钟。 43％的5-HT浓度增加,22％的5-HIAA减少。
• 参考文献:

  [1]. MAXWELL DR, et al. Relative activity of some inhibitors of mono-amine oxidase in potentiating the action of tryptamine in vitro and in vivo. Br J Pharmacol Chemother. 1961 Dec;17:310-20.

异卡波肼物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 394.5±42.0 °C at 760 mmHg
• 熔点: 98-100ºC
• 分子式: C₁₂H₁₃N₃O₂
• 分子量: 231.251
• 闪点: 192.4±27.9 °C
• 精确质量: 231.100784
• PSA: 67.16000
• LogP: 1.03
• InChIKey: XKFPYPQQHFEXRZ-UHFFFAOYSA-N
• SMILES: Cc1cc(C(=O)NNCc2ccccc2)no1
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.573
• 储存条件: -20°C Freezer

异卡波肼毒性和生态

异卡波肼安全信息

• 符号: GHS06
• 信号词: Danger
• 危害声明: H301
• 警示性声明: Missing Phrase - N15.00950417
• 危险品运输编码: UN 3249
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2934999090

异卡波肼海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

异卡波肼靶点实验

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异卡波肼英文别名

• isocarboxazide
• Benazide
• 5-Methyl-isoxazol-3-carbonsaeure-(N'-benzyl-hydrazid)
• Marplan
• Isocarboxazidum
• N'-Benzyl-5-methylisoxazol-3-carbohydrazid
• Isocarboxazida
• 3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide
• N'-benzyl-5-méthylisoxazole-3-carbohydrazide
• Isocarbonazid
• Isocarboxazid
• N'-benzyl-5-methylisoxazole-3-carbohydrazide
• N-Benzyl-N'-<5-methyl-isoxazol-3-yl>-carbonyl-hydrazin
• Isocarbossazide
• N'-Benzyl-5-methyl-1,2-oxazole-3-carbohydrazide
• Isocarboxyzid
• Enerzer
• 5-methyl-isoxazole-3-carboxylic acid-(N'-benzyl-hydrazide)
• isocarboxacid
• 5-methyl-N'-(phenylmethyl)isoxazole-3-carbohydrazide