5,6-二氯-1-乙基-1,3-二氢-2H-苯并咪唑-2-酮

• 常用名: 5,6-二氯-1-乙基-1,3-二氢-2H-苯并咪唑-2-酮
• 英文名: DCEBIO
• CAS号: 60563-36-2
• 分子量: 231.08
• 密度: 1.413g/cm3
• 沸点: N/A
• 分子式: C₉H₈Cl₂N₂O
• 熔点: 209.5-210.5 °C
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

用途

DCEBIO,1-EBIO 的衍生物,是 T84 结肠细胞中 Cl－ 分泌的极有效的激活剂。DCEBIO 通过激活 hIK1 K＋ 通道和顶端膜的 Cl－ 传导来刺激 Cl－分泌。

名称

• 中文名: 5,6-二氯-1-乙基-1,3-二氢-2H-苯并咪唑-2-酮
• 英文名: 5,6-dichloro-3-ethyl-1H-benzimidazol-2-one

生物活性

• 描述: DCEBIO,1-EBIO 的衍生物,是 T84 结肠细胞中 Cl－ 分泌的极有效的激活剂。DCEBIO 通过激活 hIK1 K＋ 通道和顶端膜的 Cl－ 传导来刺激 Cl－分泌。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 跨膜转运 >> 钾通道
• 靶点实验:

  Cl－ secretion[1]

• 参考文献:

  [1]. Hamilton KL,et al. DCEBIO stimulates Cl- secretion in the mouse jejunum. Am J Physiol Cell Physiol. 2006 Jan;290(1):C152-64.

  [2]. Singh S, et al. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11.

物理化学性质

• 密度: 1.413g/cm3
• 熔点: 209.5-210.5 °C
• 分子式: C₉H₈Cl₂N₂O
• 分子量: 231.08
• 精确质量: 230.00100
• PSA: 37.79000
• LogP: 2.65630
• InChIKey: LKHRMULASXZCLG-UHFFFAOYSA-N
• SMILES: CCn1c(=O)[nH]c2cc(Cl)c(Cl)cc21
• 折射率: 1.592
• 储存条件: 室温，干燥，密封

安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26-36
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2933990090

海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

靶点实验

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实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：qHTS Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2... 来源：NCGC 靶标：ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] External Id：UBCH001

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

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英文别名

• 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazole-2-one
• 5,6-dichloro-1-ethyl-1,3-dihydro-benzoimidazol-2-one
• DC-EBIO
• 5,6-dichloro-3-ethyl benzimidazolone
• 5,6-Dichlor-1-ethyl-benzimidazolon
• 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one
• 5,6-dichloro-1-ethyl-benzimidazolinone
• Tocris-1422
• 5,6-Dichlor-2-oxo-1-ethyl-benzimidazolin
• dichloro-EBIO