丰加霉素

更新时间：2025-08-20 17:58:29

丰加霉素结构式	常用名	丰加霉素	英文名	Toyocamycin
	CAS号	606-58-6	分子量	291.26300
	密度	1.91g/cm3	沸点	721.1ºC at 760 mmHg
	分子式	C₁₂H₁₃N₅O₄	熔点	N/A
	MSDS	中文版美版	闪点	389.9ºC

丰加霉素用途

Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物,为 X 盒结合蛋白 1 (XBP1) 抑制剂,抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂,IC50 值为 80 nM。Toyocamycin (Vengicide) 诱导凋亡,对 IRE1α 的自身磷酸化没有作用。

中文名	4-氨基-5-氰基-7-(beta-d-呋喃核糖)吡咯并[2,3-d]嘧啶
英文名	4-AMINO-5-CYANO-7-(β-D-RIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINE
英文别名	更多

描述	Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物,为 X 盒结合蛋白 1 (XBP1) 抑制剂,抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂,IC50 值为 80 nM。Toyocamycin (Vengicide) 诱导凋亡,对 IRE1α 的自身磷酸化没有作用。
相关类别	研究领域 >> 癌症信号通路 >> 细胞周期/DNA损伤 >> IRE1
靶点实验	IC50: 80 nM (XBP1 activation)[1]
参考文献	[1]. Toyocamycin, et al. Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood Cancer J. 2012 Jul;2(7):e79.

密度	1.91g/cm3
沸点	721.1ºC at 760 mmHg
分子式	C₁₂H₁₃N₅O₄
分子量	291.26300
闪点	389.9ºC
精确质量	291.09700
PSA	150.44000
InChIKey	XOKJUSAYZUAMGJ-WOUKDFQISA-N
SMILES	N#Cc1cn(C2OC(CO)C(O)C2O)c2ncnc(N)c12
折射率	1.849
储存条件	-20°C

丰加霉素毒性英文版

危害码 (欧洲)	Xi
危险品运输编码	NONH for all modes of transport

丰加霉素上游产品 0
丰加霉素下游产品 1
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