环孢菌素 D

更新时间：2024-01-10 18:46:58

环孢菌素 D结构式	常用名	环孢菌素 D	英文名	Val2-Cyclosporine
	CAS号	63775-96-2	分子量	1216.638
	密度	1.0±0.1 g/cm3	沸点	1294.7±65.0 °C at 760 mmHg
	分子式	C₆₃H₁₁₃N₁₁O₁₂	熔点	148-151ºC
	MSDS	N/A	闪点	736.8±34.3 °C
	符号	GHS02, GHS07	信号词	Danger

环孢菌素 D用途

Cyclosporin D 是 Cyclosporin A 的代谢产物,是一种弱免疫抑制剂。Cyclosporin D 作为 Cyclosporin A 定量的内标,Cyclosporin A 是一种免疫抑制药物,通过抑制钙调磷酸酶和钙调磷酸酶依赖性转录因子激活的T细胞核因子 (NFAc) 来抑制 T 细胞活化。

中文名	环孢菌素 D
英文名	Cyclosporin D
中文别名	环[L-丙氨酰-D-丙氨酰-N-甲基-L-亮氨酰-N-甲基-L-亮氨酰-N-甲基-L-缬氨酰-3-羟基-N,4-二甲基-L-2-氨基-6-辛烯酰-L-缬氨酰-N-甲基甘氨酰-N-甲基-L-亮氨酰-L-缬氨酰-N-甲基-L-亮氨酰] \| 环孢霉素D
英文别名	更多

描述	Cyclosporin D 是 Cyclosporin A 的代谢产物,是一种弱免疫抑制剂。Cyclosporin D 作为 Cyclosporin A 定量的内标,Cyclosporin A 是一种免疫抑制药物,通过抑制钙调磷酸酶和钙调磷酸酶依赖性转录因子激活的T细胞核因子 (NFAc) 来抑制 T 细胞活化。
相关类别	信号通路 >> 其他 >> 其他研究领域 >> 炎症/免疫
体外研究	环孢素D体外抑制钙/钙调素依赖的EF-2磷酸化[1]。
体内研究	环孢素D是佛波酯TPA诱导小鼠皮肤生物效应的体内有效抑制剂[1]。
参考文献	[1]. Gschwendt M, et al. The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. Biochem Biophys Res Commun. 1988 Jan 29;150(2):545-51. [2]. Kaiser P, et al. A new approach for the determination of immunosuppressive drugs using HPLC-MS/MS and Cs+ adducts. Ger Med Sci. 2006 Jan 18;4:Doc01. [3]. Minguillón J, et al. Concentrations of cyclosporin A and FK506 that inhibit IL-2 induction in human T cells do not affect TGF-beta1 biosynthesis, whereas higher doses of cyclosporin A trigger apoptosis and release of preformed TGF-beta1. J Leukoc Biol. 2005 May;77(5):748-58. Epub 2005 Feb 16.

密度	1.0±0.1 g/cm3
沸点	1294.7±65.0 °C at 760 mmHg
熔点	148-151ºC
分子式	C₆₃H₁₁₃N₁₁O₁₂
分子量	1216.638
闪点	736.8±34.3 °C
精确质量	1215.857056
PSA	275.64000
LogP	3.70
外观性状	无色至灰白色结晶固体
蒸汽压	0.0±0.6 mmHg at 25°C
折射率	1.468
储存条件	20°C

符号	GHS02, GHS07
信号词	Danger
危害声明	H225-H302 + H312 + H332-H319
警示性声明	P210-P280-P305 + P351 + P338
危害码 (欧洲)	F,Xn,T
风险声明 (欧洲)	11-20/21/22-36-39/23/24/25-23/24/25
安全声明 (欧洲)	16-36/37-45-7
危险品运输编码	UN 1648 3 / PGII
海关编码	29419090

Antimalarial activity of cyclosporins A, C and D.

Afr. J. Med. Med. Sci. 23(1) , 47-51, (1994)

Cyclosporin A (CsA) is an immunosuppressive drug widely used in organ transplants. It is also accumulated by the erythrocyte, a site that accommodates one of the stages of malaria parasite. We observe...

Enzymatic synthesis of cyclosporin A.

J. Biol. Chem. 262(36) , 17258-9, (1987)

An enzyme fraction, isolated from crude extracts of the fungus Tolypocladium inflatum, strain 7939/F, is able to synthesize the undecapeptide cyclosporin A. The formation of cyclosporin A was monitore...

In vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines A, C, D and metabolites M1, M17 and M21.

Immunopharmacol. Immunotoxicol. 15(2-3) , 163-77, (1993)

Cyclosporine A (CsA) and its major metabolites: M1, M17 and M21 and two analogues: cyclosporines C (CsC) and D (CsD), were studied for their capacity to interfere with different in vitro activation pa...

33-[(4E)-1-Hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21,30-triisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21,30-tri(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

CyclosporinD

cyclosporine D

Val2-Cyclosporine

1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, 33-[(4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21,30-tris(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-

33-[(4E)-1-Hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21,30-triisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

7-L-Valinecyclosporin A

Cyclosporin Impurity 4