2-苯甲酰氨基-1,4-萘醌

• 常用名: 2-苯甲酰氨基-1,4-萘醌
• 英文名: PPM-18
• CAS号: 65240-86-0
• 分子量: 277.274
• 密度: 1.4±0.1 g/cm3
• 沸点: 517.5±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₁NO₃
• 熔点: N/A
• 闪点: 208.2±30.3 °C

2-苯甲酰氨基-1,4-萘醌用途

PPM-18(NSC 73233)是一种有效的抗炎剂,可抑制一氧化氮合酶的表达。PPM-18通过阻断NF-κB与启动子的结合,是一种有效的iNOS表达抑制剂[1]。PPM-18是维生素K的类似物,通过ROS和AMPK信号通路诱导膀胱癌细胞自噬和凋亡【2】。

2-苯甲酰氨基-1,4-萘醌名称

• 中文名: 2-苯甲酰氨基-1,4-萘醌
• 英文名: N-(1,4-dioxonaphthalen-2-yl)benzamide

2-苯甲酰氨基-1,4-萘醌生物活性

• 描述: PPM-18(NSC 73233)是一种有效的抗炎剂,可抑制一氧化氮合酶的表达。PPM-18通过阻断NF-κB与启动子的结合,是一种有效的iNOS表达抑制剂[1]。PPM-18是维生素K的类似物,通过ROS和AMPK信号通路诱导膀胱癌细胞自噬和凋亡【2】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 免疫及炎症 >> 一氧化氮合酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. S M Yu, et al. Inhibition of nitric oxide synthase expression by PPM-18, a novel anti-inflammatory agent, in vitro and in vivo. Biochem J. 1997 Dec 1;328 ( Pt 2)(Pt 2):363-9.

  [2]. Huiai Lu, et al. PPM-18, an Analog of Vitamin K, Induces Autophagy and Apoptosis in Bladder Cancer Cells Through ROS and AMPK Signaling Pathways. Front Pharmacol. 2021 Jul 9;12:684915.

2-苯甲酰氨基-1,4-萘醌物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 517.5±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₁NO₃
• 分子量: 277.274
• 闪点: 208.2±30.3 °C
• 精确质量: 277.073883
• PSA: 63.24000
• LogP: 2.09
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.667

2-苯甲酰氨基-1,4-萘醌靶点实验

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2-苯甲酰氨基-1,4-萘醌英文别名

• 2-benzoylamino-1,4-naphthoquinone
• ppm-18
• N-(1,4-Dioxo-1,4-dihydro-2-naphthalenyl)benzamide
• 2-Benzamino-1,4-naphthochinon