抗生素LL Z1640-4

• 常用名: 抗生素LL Z1640-4
• 英文名: 5,6,7,15-tetrahydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaen-13-one
• CAS号: 66018-41-5
• 分子量: 364.39000
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₄O₇
• 熔点: N/A
• 闪点: N/A

抗生素LL Z1640-4用途

LL-Z1640-4是一种有效的p38/JNK信号抑制剂。LL-Z1640-4显著降低转染MLK4 siRNA的肝癌细胞中p38和JNK的激活。LL-Z1640-4显著减弱MLK4敲除诱导的ROS产生。LL-Z1640-4显著减少转染siMLK4的肝癌细胞中的凋亡细胞[1][2]。

抗生素LL Z1640-4名称

• 中文名: 抗生素LL Z1640-4
• 英文名: 5,6,7,15-tetrahydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaen-13-one

抗生素LL Z1640-4生物活性

• 描述: LL-Z1640-4是一种有效的p38/JNK信号抑制剂。LL-Z1640-4显著降低转染MLK4 siRNA的肝癌细胞中p38和JNK的激活。LL-Z1640-4显著减弱MLK4敲除诱导的ROS产生。LL-Z1640-4显著减少转染siMLK4的肝癌细胞中的凋亡细胞[1][2]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  信号通路 >> MAPK/ERK信号通路 >> JNK
• 体外研究: LL-Z1640-4显著恢复siMLK4减少的迁移和侵袭细胞数量,并显著上调MMP2和波形蛋白的表达[2]。
• 参考文献:

  [1]. Ellestad George A, et al. New zearalenone related macrolides and isocoumarins from an unidentified fungus. The Journal of Organic Chemistry, 1978,43(12):2339–2343.

  [2]. Li Y, Zuo H, Wang H, Hu A. Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling. Biomed Pharmacother. 2019 Aug;116:108749.

抗生素LL Z1640-4物理化学性质

• 分子式: C₁₉H₂₄O₇
• 分子量: 364.39000
• 精确质量: 364.15200
• PSA: 116.45000
• LogP: 1.39200
• InChIKey: BPOLRDGTYHVUAY-UHFFFAOYSA-N
• SMILES: COc1cc(O)c2c(c1)C=CCC(O)C(O)C(O)C=CCC(C)OC2=O

抗生素LL Z1640-4靶点实验

查看更多实验

实验名称：Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTS assay 来源：ChEMBL 靶标：MDA-MB-435 External Id：CHEMBL1804146

实验名称：Cytotoxicity against human SF268 cells after 72 hrs by MTS assay 来源：ChEMBL 靶标：SF-268 External Id：CHEMBL1804145

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Trypanosoma brucei RNA editing ligase 1 External Id：TBREL1_INH_FRET_1536_1X%INH PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Antimicrobial activity against Staphylococcus aureus by agar plate diffusion assay 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL1804148

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify act... 来源：The Scripps Research Institute Molecular Screening Center 靶标：TTR [Homo sapiens] External Id：TTR_ACT_LUMI_1536_1X%ACT PRUN

实验名称：Antimicrobial activity against Escherichia coli by agar plate diffusion assay 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL1804147

实验名称：Antimicrobial activity against Bacillus subtilis by agar plate diffusion assay 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL1804150

实验名称：Innate immunity-regulating activity in Drosophila Dpt-lacZ larvae assessed as suppres... 来源：ChEMBL 靶标：Drosophila External Id：CHEMBL3594626

实验名称：Antimicrobial activity against Mycobacterium smegmatis by agar plate diffusion assay 来源：ChEMBL 靶标：Mycolicibacterium smegmatis External Id：CHEMBL1804149

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抗生素LL Z1640-4英文别名

• Antibiotic LL Z1640-4