格里西轮

更新时间：2025-08-26 20:06:20

格里西轮结构式	常用名	格里西轮	英文名	Glycyrin
	CAS号	66056-18-6	分子量	382.41
	密度	1.3±0.1 g/cm3	沸点	614.1±55.0 °C at 760 mmHg
	分子式	C₂₂H₂₂O₆	熔点	N/A
	MSDS	N/A	闪点	216.2±25.0 °C

格里西轮用途

Glycyrin 是甘草的 PPAR-γ 配体。Glycyrin 可以降低遗传性糖尿病小鼠的血糖水平。Glycyrin 还具有抗菌活性。

中文名	格里西轮
英文名	glycyrin
英文别名	更多

描述	Glycyrin 是甘草的 PPAR-γ 配体。Glycyrin 可以降低遗传性糖尿病小鼠的血糖水平。Glycyrin 还具有抗菌活性。
相关类别	研究领域 >> 感染信号通路 >> 细胞周期/DNA损伤 >> PPAR 研究领域 >> 代谢疾病信号通路 >> 抗感染 >> 细菌
参考文献	[1]. Kuroda M,et, al. Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4267-72. [2]. Tanaka Y, et, al. Antibacterial compounds of licorice against upper airway respiratory tract pathogens. J Nutr Sci Vitaminol (Tokyo). 2001 Jun;47(3):270-3. [3]. Wang Q, et, al. Metabolites identification of glycyrin and glycyrol, bioactive coumarins from licorice. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 1:983-984:39-46.

描述

Glycyrin 是甘草的 PPAR-γ 配体。Glycyrin 可以降低遗传性糖尿病小鼠的血糖水平。Glycyrin 还具有抗菌活性。

相关类别

研究领域 >> 感染

信号通路 >> 细胞周期/DNA损伤 >> PPAR

研究领域 >> 代谢疾病

信号通路 >> 抗感染 >> 细菌

参考文献

[1]. Kuroda M,et, al. Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4267-72.

[2]. Tanaka Y, et, al. Antibacterial compounds of licorice against upper airway respiratory tract pathogens. J Nutr Sci Vitaminol (Tokyo). 2001 Jun;47(3):270-3.

[3]. Wang Q, et, al. Metabolites identification of glycyrin and glycyrol, bioactive coumarins from licorice. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 1:983-984:39-46.

密度	1.3±0.1 g/cm3
沸点	614.1±55.0 °C at 760 mmHg
分子式	C₂₂H₂₂O₆
分子量	382.41
闪点	216.2±25.0 °C
精确质量	382.141632
PSA	89.13000
LogP	5.75
InChIKey	FWWGXZYUURXJLK-UHFFFAOYSA-N
SMILES	COc1cc2oc(=O)c(-c3ccc(O)cc3O)cc2c(OC)c1CC=C(C)C
外观性状	黄色粉末
蒸汽压	0.0±1.8 mmHg at 25°C
折射率	1.615
储存条件	2-8℃，干燥，密闭

危害码 (欧洲)	Xi
海关编码	2932209090

海关编码	2932209090
中文概述	2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

实验名称：Inhibition of Spanish flu (A/Bervig_Mission/1/18) neuraminidase at 200 uM
来源：ChEMBL
靶标：N/A
External Id：CHEMBL1073436

实验名称：Body weight of the fasted diabetic KK-Ay mice on day 10 was measured
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL711375

实验名称：Inhibition of Spanish flu (A/Bervig_Mission/1/18) neuraminidase by noncompetitive inh...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL1073435

实验名称：Body weight of the non-fasted diabetic KK-Ay mice on day 0 was measured
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL711533

实验名称：Body weight of the non-fasted diabetic KK-Ay mice on day 7 was measured
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL711535

实验名称：Body weight of the non-fasted diabetic KK-Ay mice on day 4 was measured
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL711534

实验名称：HIV Cellular Data
来源：NIAID
靶标：N/A
External Id：HIV Cellular Data

实验名称：Activation of NRF2 transcription in human HepG2C8 cells at 10 uM after 6 hrs by lucif...
来源：ChEMBL
靶标：Nuclear factor erythroid 2-related factor 2
External Id：CHEMBL3810627

实验名称：Antibacterial activity against Bacillus subtilis NBRC 3134 after overnight incubation...
来源：ChEMBL
靶标：Bacillus subtilis
External Id：CHEMBL3999570

实验名称：Average food intake of the diabetic KK-Ay mice was measured from total intake amount/...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL714491

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3-(2,4-dihydroxyphenyl)-5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-2-one

3-(2,4-dihydroxyphenyl)-5,7-dimethoxy-6-(3-methylbut-2-enyl)chromen-2-one

3-(2,4-Dihydroxyphenyl)-5,7-dimethoxy-6-(3-methyl-2-buten-1-yl)-2H-chromen-2-one

Glycyrin

3-(2,4-Dihydroxy-phenyl)-5,7-dimethoxy-6-(3-methyl-but-2-enyl)-1-benzopyran-2-one