3-(2,4-Dihydroxybenzylidene)-5-(4-methoxyphenyl)-2(3H)-furanone

• 常用名: 3-(2,4-Dihydroxybenzylidene)-5-(4-methoxyphenyl)-2(3H)-furanone
• 英文名: 3-(2,4-Dihydroxybenzylidene)-5-(4-methoxyphenyl)-2(3H)-furanone
• CAS号: 6621-92-7
• 分子量: 310.30100
• 密度: 1.408g/cm3
• 沸点: 617.2ºC at 760 mmHg
• 分子式: C₁₈H₁₄O₅
• 熔点: N/A
• 闪点: 231.7ºC

用途

ALR-6 是 5-脂氧合酶 (5-LOX) 激活蛋白 FLAP 的拮抗剂,具有抗炎活性。ALR-6 在促炎 M1-MDM 中有效抑制 5-LOX 产物形成 (>80%),对 5-LOX 直接抑制效果不显著。

名称

• 英文名: 3-[(2,4-dihydroxyphenyl)methylidene]-5-(4-methoxyphenyl)furan-2-one

生物活性

• 描述: ALR-6 是 5-脂氧合酶 (5-LOX) 激活蛋白 FLAP 的拮抗剂,具有抗炎活性。ALR-6 在促炎 M1-MDM 中有效抑制 5-LOX 产物形成 (>80%),对 5-LOX 直接抑制效果不显著。
• 相关类别:
  信号通路 >> 免疫及炎症 >> FLAP
  研究领域 >> 炎症/免疫
• 靶点实验:

  FLAP[1]

• 参考文献:

  [1]. Cerchia C et al. Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening. Eur J Med Chem. 2023 Nov 8;263:115932.

物理化学性质

• 密度: 1.408g/cm3
• 沸点: 617.2ºC at 760 mmHg
• 分子式: C₁₈H₁₄O₅
• 分子量: 310.30100
• 闪点: 231.7ºC
• 精确质量: 310.08400
• PSA: 75.99000
• LogP: 3.08770
• InChIKey: ZOHPXEDJWXZOLY-JYRVWZFOSA-N
• SMILES: COc1ccc(C2=CC(=Cc3ccc(O)cc3O)C(=O)O2)cc1
• 折射率: 1.701

靶点实验

查看更多实验

实验名称：Inhibition of human sEH assessed as enzyme remaining activity at 10 uM relative to co... 来源：ChEMBL 靶标：Bifunctional epoxide hydrolase 2 External Id：CHEMBL5528214

实验名称：Inhibition of human mPGES-1 assessed as enzyme remaining activity at 10 uM relative t... 来源：ChEMBL 靶标：Prostaglandin E synthase External Id：CHEMBL5528213

实验名称：Inhibition of 5-LOX in human Neutrophil assessed as enzyme remaining activity at 10 u... 来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase External Id：CHEMBL5528206

实验名称：Inhibition of 5-LOX in human Neutrophil assessed as enzyme remaining activity at 10 u... 来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase External Id：CHEMBL5528205

实验名称：Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assesse... 来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase External Id：CHEMBL5528204

实验名称：Effect on lipid mediator formation in human M1-like phenotype MDM cells by measuring ... 来源：ChEMBL 靶标：Macrophage cell line External Id：CHEMBL5528250

实验名称：Effect on lipid mediator formation in human M1-like phenotype MDM cells by measuring ... 来源：ChEMBL 靶标：Macrophage cell line External Id：CHEMBL5528249

实验名称：Effect on lipid mediator formation in human M1-like phenotype MDM cells by measuring ... 来源：ChEMBL 靶标：Macrophage cell line External Id：CHEMBL5528248

实验名称：Effect on lipid mediator formation in human M1-like phenotype MDM cells by measuring ... 来源：ChEMBL 靶标：Macrophage cell line External Id：CHEMBL5528247

实验名称：Effect on lipid mediator formation in human M1-like phenotype MDM cells by measuring ... 来源：ChEMBL 靶标：Macrophage cell line External Id：CHEMBL5528246

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