二氢鱼藤酮

• 常用名: 二氢鱼藤酮
• 英文名: Dihydrorotenone
• CAS号: 6659-45-6
• 分子量: 396.433
• 密度: 1.3±0.1 g/cm3
• 沸点: 553.9±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₄O₆
• 熔点: 216 °C
• 闪点: 241.6±30.2 °C

二氢鱼藤酮用途

Dihydrorotenone 是一种天然杀虫剂,是一种线粒体 (mitochondrial) 抑制剂。Dihydrorotenone 可能诱发帕金森综合症。Dihydrorotenone 通过触发内质网应激并激活 p38 信号通路来诱导人浆细胞凋亡 (apoptosis)

二氢鱼藤酮名称

• 中文名: 二氢鱼藤酮
• 英文名: Dihydrorotenone (VAN)

二氢鱼藤酮生物活性

• 描述: Dihydrorotenone 是一种天然杀虫剂,是一种线粒体 (mitochondrial) 抑制剂。Dihydrorotenone 可能诱发帕金森综合症。Dihydrorotenone 通过触发内质网应激并激活 p38 信号通路来诱导人浆细胞凋亡 (apoptosis)
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  信号通路 >> 代谢酶/蛋白酶 >> 线粒体代谢
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Zhang J, et al. The natural pesticide dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway. PLoS One. 2013 Jul 26;8(7):e69911.

二氢鱼藤酮物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 553.9±50.0 °C at 760 mmHg
• 熔点: 216 °C
• 分子式: C₂₃H₂₄O₆
• 分子量: 396.433
• 闪点: 241.6±30.2 °C
• 精确质量: 396.157288
• PSA: 63.22000
• LogP: 4.82
• InChIKey: DTFARBHXORYQBF-HBGVWJBISA-N
• SMILES: COc1cc2c(cc1OC)C1C(=O)c3ccc4c(c3OC1CO2)CC(C(C)C)O4
• 外观性状: 粉末
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.580
• 储存条件: 2-8°C，密封，干燥

二氢鱼藤酮毒性和生态

二氢鱼藤酮靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Compound was evaluated for the inhibitory activity against Histamine in guinea pig il... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL857443

实验名称：Compound was evaluated for the inhibitory activity against Acetylcholine in guinea pi... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL686258

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Compound was evaluated for the inhibitory activity against Serotonin in guinea pig il... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL686259

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

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二氢鱼藤酮英文别名

• 1',2'-dihydrorotenone
• 1-Dihydrorotenon
• Dihydrorotenone
• 6'.7'-Dihydro-rotenon
• (2R,6aS,12aS)-2-Isopropyl-8,9-dimethoxy-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one
• 6',7'-dihydrorotenone