二氢鱼藤酮
二氢鱼藤酮用途
Dihydrorotenone 是一种天然杀虫剂,是一种线粒体 (mitochondrial) 抑制剂。Dihydrorotenone 可能诱发帕金森综合症。Dihydrorotenone 通过触发内质网应激并激活 p38 信号通路来诱导人浆细胞凋亡 (apoptosis)
点击显示
二氢鱼藤酮名称
[ CAS 号 ]:
6659-45-6
[ 中文名 ]:
二氢鱼藤酮
[ 英文名 ]:
Dihydrorotenone
[英文别名 ]:
- 1',2'-dihydrorotenone
- 1-Dihydrorotenon
- Dihydrorotenone
- 6'.7'-Dihydro-rotenon
- 6',7'-dihydrorotenone
二氢鱼藤酮生物活性
[ 描述 ]:
Dihydrorotenone 是一种天然杀虫剂,是一种线粒体 (mitochondrial) 抑制剂。Dihydrorotenone 可能诱发帕金森综合症。Dihydrorotenone 通过触发内质网应激并激活 p38 信号通路来诱导人浆细胞凋亡 (apoptosis)
[ 相关类别 ]:
[参考文献]
二氢鱼藤酮物理化学性质
[ 密度 ]:
1.3±0.1 g/cm3
[ 沸点 ]:
553.9±50.0 °C at 760 mmHg
[ 熔点 ]:
216 °C
[ 分子式 ]:
C23H24O6
[ 分子量 ]:
396.433
[ 闪点 ]:
241.6±30.2 °C
[ 精确质量 ]:
396.157288
[ PSA ]:
63.22000
[ LogP ]:
4.82
[ 外观性状 ]:
粉末
[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C
[ 折射率 ]:
1.580
[ 储存条件 ]:
2-8°C，密封，干燥
二氢鱼藤酮毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DJ2623100
- CHEMICAL NAME :
- (1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6a-al phah)-one, 1,2,12,12a-alpha-tetrahydro- 2-alpha-isopropyl-8,9-dimethoxy-
- CAS REGISTRY NUMBER :
- 6659-45-6
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C23-H24-O6
- MOLECULAR WEIGHT :
- 396.47
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2500 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,364,1953
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL. Volume(issue)/page/year: 29,429,1937
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL. Volume(issue)/page/year: 29,429,1937 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4616 mg/kg/57W-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,364,1953
点击显示
二氢鱼藤酮合成路线
二氢鱼藤酮上下游产品
二氢鱼藤酮上游产品
二氢鱼藤酮下游产品
推荐生产厂家/供应商：
相关化合物
【二氢鱼藤酮】化源网提供二氢鱼藤酮CAS号6659-45-6，二氢鱼藤酮MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询二氢鱼藤酮上化源网，专业又轻松。>>电脑版：二氢鱼藤酮
标题：二氢鱼藤酮_用途_密度_熔点_二氢鱼藤酮CAS号【6659-45-6】_化源网 地址：https://m.chemsrc.com/mip/cas/6659-45-6_173448.html