(S)-N-(2-氧代四氢呋喃-3-基)丁酰胺

• 常用名: (S)-N-(2-氧代四氢呋喃-3-基)丁酰胺
• 英文名: N-Butanoyl-L-homoserine lactone
• CAS号: 67605-85-0
• 分子量: 171.194
• 密度: 1.1±0.1 g/cm3
• 沸点: 428.1±34.0 °C at 760 mmHg
• 分子式: C₈H₁₃NO₃
• 熔点: N/A
• 闪点: 212.7±25.7 °C

(S)-N-(2-氧代四氢呋喃-3-基)丁酰胺用途

N-Butanoyl-L-homoserine lactone 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。N-Butanoyl-L-homoserine lactone 具有抗菌活性,可用于抗菌生物膜。

(S)-N-(2-氧代四氢呋喃-3-基)丁酰胺名称

• 中文名: N-[(3S)-四氢-2-氧代-3-呋喃基]丁酰胺
• 英文名: N-[(3S)-2-oxooxolan-3-yl]butanamide

(S)-N-(2-氧代四氢呋喃-3-基)丁酰胺生物活性

• 描述: N-Butanoyl-L-homoserine lactone 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。N-Butanoyl-L-homoserine lactone 具有抗菌活性,可用于抗菌生物膜。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗体- 药物偶联物 >> ADC连接器
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  Cleavable

• 体外研究: ADC由抗体组成,抗体通过ADC连接物连接ADC细胞毒素。
• 参考文献:

  [1]. Keith Alan Charlton, et al. Methods for the Treatment of an Infectious Bacterial Disease with an Anti-Lactone or Lactone Derived Signal Molecules Antibody. US20130045208A1

(S)-N-(2-氧代四氢呋喃-3-基)丁酰胺物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 428.1±34.0 °C at 760 mmHg
• 分子式: C₈H₁₃NO₃
• 分子量: 171.194
• 闪点: 212.7±25.7 °C
• 精确质量: 171.089539
• PSA: 55.40000
• LogP: -1.10
• InChIKey: VFFNZZXXTGXBOG-LURJTMIESA-N
• SMILES: CCCC(=O)NC1CCOC1=O
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.476
• 储存条件: 2-8°C

(S)-N-(2-氧代四氢呋喃-3-基)丁酰胺靶点实验

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(S)-N-(2-氧代四氢呋喃-3-基)丁酰胺英文别名

• C4-homoserine lactone
• N-Butyryl-DL-homoserin-lacton
• HL4
• N-Butyryl-L-homoserine lactone
• N-[(3S)-2-oxotetrahydrofuran-3-yl]butanamide
• (+)-a(S)-butyr-amido-r-butyrolactone
• N-[(3S)-2-Oxotetrahydro-3-furanyl]butanamide
• butanoyl homoserine lactone