CAY10698

• 常用名: CAY10698
• 英文名: CAY10698
• CAS号: 684236-01-9
• 分子量: 391.46
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₇N₃O₄S₂
• 熔点: N/A
• 闪点: N/A

CAY10698用途

CAY10698(化合物1)是12-脂氧合酶(12-LOX)的有效和选择性抑制剂,IC50为5.1μM。CAY10698对5-LOX、15-LOX-1、15-LOX-2和COX-1/2无效[1]。

CAY10698名称

• 中文名: 4-((2-羟基-3-甲氧基苄基)氨基)-N-(噻唑-2-基)苯磺酰胺
• 英文名: CAY10698

CAY10698生物活性

• 描述: CAY10698(化合物1)是12-脂氧合酶(12-LOX)的有效和选择性抑制剂,IC50为5.1μM。CAY10698对5-LOX、15-LOX-1、15-LOX-2和COX-1/2无效[1]。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶
• 参考文献:

  [1]. David J. Maloney, et al. 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase.

CAY10698物理化学性质

• 分子式: C₁₇H₁₇N₃O₄S₂
• 分子量: 391.46
• InChIKey: CENSVXZQMJBVHY-UHFFFAOYSA-N
• SMILES: COc1cccc(CNc2ccc(S(=O)(=O)Nc3nccs3)cc2)c1O
• 外观性状: 淡粉色粉末
• 储存条件: 2-8°C， 密封， 干燥

CAY10698安全信息

• 危害码 (欧洲): Xn

CAY10698靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：NCATS Kinetic Aqueous Solubility Profiling 来源：NCGC 靶标：N/A External Id：ADME-solubility1

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Confirmatory qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12... 来源：NCGC External Id：12hLO-f-round2

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：NCATS Parallel Artificial Membrane Permeability Assay (PAMPA) Profiling 来源：NCGC 靶标：N/A External Id：ADME-PAMPA1

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