甲磺酸普立地诺

• 常用名: 甲磺酸普立地诺
• 英文名: Pridinol Methanesulfonate Salt
• CAS号: 6856-31-1
• 分子量: 391.52400
• 密度: N/A
• 沸点: 585.1ºC at 760 mmHg
• 分子式: C₂₁H₂₉NO₄S
• 熔点: 152.5-155ºC
• 闪点: 307.6ºC
• 符号: GHS07
• 信号词: Warning

甲磺酸普立地诺用途

甲磺酸普利地诺是一种口服活性强的中枢抗胆碱能药物,可作为肌肉松弛剂[1]。

甲磺酸普立地诺名称

• 中文名: Alpha,Alpha-二苯基-1-哌啶丙醇
• 英文名: Pridinol Methanesulfonate Salt
• 中文别名: α,α-二苯基-1-哌啶丙醇 | 1-(3-羟基-1,1-二苯基丙基)哌啶鎓甲烷磺酸盐 | 甲磺酸普立地诺

甲磺酸普立地诺生物活性

• 描述: 甲磺酸普利地诺是一种口服活性强的中枢抗胆碱能药物,可作为肌肉松弛剂[1]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> 疼痛
• 参考文献:

  [1]. Richter M, et al. Pharmacokinetics of oral pridinol: Results of a randomized, crossover bioequivalence trial in healthy subjects. Int J Clin Pharmacol Ther. 2021 Jun;59(6):471-477.

  [2]. Duperray, B., et al. The fate of pridinol in the organism: Pharmacokinetics and distribution in animals. European Journal of Drug Metabolism and Pharmacokinetics 2, 121–130 (1977).

甲磺酸普立地诺物理化学性质

• 沸点: 585.1ºC at 760 mmHg
• 熔点: 152.5-155ºC
• 分子式: C₂₁H₂₉NO₄S
• 分子量: 391.52400
• 闪点: 307.6ºC
• 精确质量: 391.18200
• PSA: 86.22000
• LogP: 4.32120
• InChIKey: VNJHUUNVDMYCRH-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)O.OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1
• 外观性状: 白色至灰白色结晶粉末
• 储存条件: 2-8°C
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:2

  3.氢键受体数量:5

  4.可旋转化学键数量:5

  5.互变异构体数量:无

  6.拓扑分子极性表面积86.2

  7.重原子数量:27

  8.表面电荷:0

  9.复杂度:386

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

甲磺酸普立地诺安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H312-H332
• 警示性声明: P280
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): 36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3

甲磺酸普立地诺靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Validation... 来源：NMMLSC 靶标：ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens] External Id：UNMCMD_ABCB6_1o_ValidationSet

实验名称：Confirmed allosteric antagonists of M1 Muscarinic receptor 来源：1043 靶标：Muscarinic acetylcholine receptor M1 External Id：SAID_435034

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甲磺酸普立地诺英文别名

• 1,1-diphenyl-3-piperidin-1-ylpropan-1-ol,methanesulfonic acid