去氢齿孔酸

• 常用名: 去氢齿孔酸
• 英文名: Dehydroeburicoic acid
• CAS号: 6879-05-6
• 分子量: 468.71100
• 密度: 1.07±0.1 g/cm3
• 沸点: N/A
• 分子式: C₃₁H₄₈O₃
• 熔点: N/A
• 闪点: N/A

去氢齿孔酸用途

Dehydrotrametenolic acid 是从茯苓 (Poria cocos) 的菌核中分离的甾醇。Dehydrotrametenolic acid 通过 caspase-3 途径诱导细胞凋亡。Dehydrotrametenolic acid 具有抗肿瘤活性,抗炎,抗糖尿病作用。

去氢齿孔酸名称

• 中文名: 二氢齿孔酸
• 英文名: Dehydroeburicoic acid
• 中文别名: 去氢齿孔酸

去氢齿孔酸生物活性

• 描述: Dehydrotrametenolic acid 是从茯苓 (Poria cocos) 的菌核中分离的甾醇。Dehydrotrametenolic acid 通过 caspase-3 途径诱导细胞凋亡。Dehydrotrametenolic acid 具有抗肿瘤活性,抗炎,抗糖尿病作用。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞凋亡 >> 胱天蛋白酶
  研究领域 >> 炎症/免疫
• 靶点实验:

  Caspase-3

• 体内研究: 脱氢曲美烯醇酸选择性地抑制GI50值为40μM的H-ras转化细胞的生长[1]。
• 参考文献:

  [1]. Kang HM, et al. Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway. Life Sci. 2006 Jan 2;78(6):607-13.

去氢齿孔酸物理化学性质

• 密度: 1.07±0.1 g/cm3
• 分子式: C₃₁H₄₈O₃
• 分子量: 468.71100
• 精确质量: 468.36000
• PSA: 57.53000
• LogP: 7.56580
• InChIKey: ONFPYGOMAADWAT-OXUZYLMNSA-N
• SMILES: C=C(CCC(C(=O)O)C1CCC2(C)C3=CCC4C(C)(CCC(O)C4(C)C)C3=CCC12C)C(C)C
• 储存条件: 2-8°C，密封，干燥
• 水溶解性: Insuluble (6.1E-6 g/L) (25 ºC)

去氢齿孔酸靶点实验

查看更多实验

实验名称：Antiproliferative activity against human CCRF-CEM cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：CCRF-CEM External Id：CHEMBL3994836

实验名称：Antiproliferative activity against human MOLT4 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：MOLT-4 External Id：CHEMBL3994835

实验名称：Antiproliferative activity against human K562 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：K562 External Id：CHEMBL3994838

实验名称：Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL3994837

实验名称：Cytotoxicity against human HS68 cells at 25 to 200 uM after 48 hrs by SRB assay 来源：ChEMBL 靶标：Hs68 External Id：CHEMBL3107296

实验名称：Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells a... 来源：ChEMBL 靶标：Human gammaherpesvirus 4 External Id：CHEMBL904902

实验名称：Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells a... 来源：ChEMBL 靶标：Human gammaherpesvirus 4 External Id：CHEMBL904903

实验名称：Induction of ROS scavenging activity in HUVEC assessed as reduction in high glucose-i... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL4344060

实验名称：Cytotoxicity against human L02 cells incubated for 24 hrs by MTT assay 来源：ChEMBL 靶标：L02 External Id：CHEMBL4344059

实验名称：Cytotoxicity against human SW480 cells incubated for 24 hrs by MTT assay 来源：ChEMBL 靶标：SW480 External Id：CHEMBL4344058

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去氢齿孔酸英文别名

• (R)-2-((3S,5R,10S,13R,14R,17R)-3-Hydroxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-methyl-5-methylene-heptanoic acid
• 3β-Hydroxy-eburica-7,9(11),24(28)-trien-21-saeure
• dehydroeburicoic acid
• 3β-Hydroxy-24-methylen-lanosta-7,9(11)-dien-21-saeure
• 3β-hydroxy-eburica-7,9(11),24(28)-trien-21-oic acid