CM10

• 常用名: CM10
• 英文名: CM 10
• CAS号: 692269-09-3
• 分子量: 321.42
• 密度: 1.12±0.1 g/cm3(Predicted)
• 沸点: 512.4±52.0 °C(Predicted)
• 分子式: C₂₀H₂₃N₃O
• 熔点: N/A
• 闪点: N/A

CM10用途

CM10 是一种有效的,选择性乙醛脱氢酶 1A 家族抑制剂 (ALDH1Ai),对于 ALDH1A1,ALDH1A2 和 ALDH1A3 的 IC50 分别为 1700、740 和 640 nM。CM10 对 ALDH 家族其他成员没有抑制作用。CM10 可以调节新陈代谢并具有抗癌活性。

CM10名称

• 中文名: 2-烯丙基-6-(((1-丙基-1H-苯并[d]咪唑-2-基)氨基)甲基)苯酚
• 英文名: CM10

CM10生物活性

• 描述: CM10 是一种有效的,选择性乙醛脱氢酶 1A 家族抑制剂 (ALDH1Ai),对于 ALDH1A1,ALDH1A2 和 ALDH1A3 的 IC50 分别为 1700、740 和 640 nM。CM10 对 ALDH 家族其他成员没有抑制作用。CM10 可以调节新陈代谢并具有抗癌活性。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 醛脱氢酶(ALDH)
  研究领域 >> 癌症
  研究领域 >> 代谢疾病
• 靶点实验:

  IC50: 1700 nM (ALDH1A1), 740 nM (ALDH1A2) and 640 nM (ALDH1A3)[1]

• 体外研究: CM10(12.5、25、50、100μM；1小时)抑制活细胞中的氟化物活性,并优先消耗CD133+卵巢癌干细胞(CSCs)[1]。CM10诱导细胞/核肿胀坏死表型[1]。
• 参考文献:

  [1]. Chefetz I, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019 Mar 12;26(11):3061-3075.e6.

CM10物理化学性质

• 密度: 1.12±0.1 g/cm3(Predicted)
• 沸点: 512.4±52.0 °C(Predicted)
• 分子式: C₂₀H₂₃N₃O
• 分子量: 321.42
• InChIKey: ZFHWEWJDCFGRBO-UHFFFAOYSA-N
• SMILES: C=CCc1cccc(CNc2nc3ccccc3n2CCC)c1O
• 外观性状: 固体
• 储存条件: 2-8°C， 密封， 干燥， 避光

CM10安全信息

• 危害码 (欧洲): Xn

CM10靶点实验

查看更多实验

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