普立非酮

• 常用名: 普立非酮
• 英文名: Prifelone
• CAS号: 69425-13-4
• 分子量: 316.45800
• 密度: 1.095g/cm3
• 沸点: 422ºC at 760 mmHg
• 分子式: C₁₉H₂₄O₂S
• 熔点: N/A
• 闪点: 209ºC

普立非酮用途

Prifelone (R 830; R 830T; S 16820) 是一种二叔丁基苯酚,具有抗炎作用和抗氧化活性。Prifelone 抑制豚鼠肺氧合酶和牛精囊环氧合酶。

普立非酮名称

• 中文名: 普立非酮
• 英文名: (3,5-ditert-butyl-4-hydroxyphenyl)-thiophen-2-ylmethanone

普立非酮生物活性

• 描述: Prifelone (R 830; R 830T; S 16820) 是一种二叔丁基苯酚,具有抗炎作用和抗氧化活性。Prifelone 抑制豚鼠肺氧合酶和牛精囊环氧合酶。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 免疫及炎症 >> COX
• 参考文献:

  [1]. Moore GG, et al. 2,6-Di-tert-butyl-4-(2'-thenoyl)phenol(R-830): a novel nonsteroidal anti-inflammatory agent with antioxidant properties. Agents Actions. 1982 Dec;12(5-6):674-83.

普立非酮物理化学性质

• 密度: 1.095g/cm3
• 沸点: 422ºC at 760 mmHg
• 分子式: C₁₉H₂₄O₂S
• 分子量: 316.45800
• 闪点: 209ºC
• 精确质量: 316.15000
• PSA: 65.54000
• LogP: 5.27970
• InChIKey: WAAVMZLJRXYRMA-UHFFFAOYSA-N
• SMILES: CC(C)(C)c1cc(C(=O)c2cccs2)cc(C(C)(C)C)c1O
• 折射率: 1.557

普立非酮靶点实验

查看更多实验

实验名称：Inhibitory activity against lipoxygenase (LO) at 1 uM concentration 来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase External Id：CHEMBL712611

实验名称：Inhibitory activity against Prostaglandin G/H synthase at 10 uM concentration 来源：ChEMBL 靶标：Prostaglandin G/H synthase 1 External Id：CHEMBL762421

实验名称：Inhibitory activity against cyclooxygenase (CO) at 1 uM concentration 来源：ChEMBL 靶标：Prostaglandin G/H synthase 1 External Id：CHEMBL845856

实验名称：Inhibitory activity against developing adjuvant-induced arthritis (Dev AA) in rat at ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL785773

实验名称：Comparative activity versus Dihydrodimethylbenzofurans in the CPE (Carrageenan paw ed... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL772995

实验名称：Inhibitory activity against lipoxygenase (LO) at 10 uM concentration 来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase External Id：CHEMBL712610

实验名称：Inhibition of human neutrophil 5-lipoxygenase 来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase External Id：CHEMBL618006

实验名称：Inhibitory activity against developing adjuvant-induced arthritis (Dev AA) in rat at ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL785775

实验名称：Inhibition of human platelet Prostaglandin G/H synthase 来源：ChEMBL 靶标：Prostaglandin G/H synthase 1 External Id：CHEMBL762412

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普立非酮英文别名

• Prifelona [INN-Spanish]
• 2,6-di-tert-butyl-4-(2'-thenoyl)phenol
• (3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-thienylmethanone
• (3,5-di-tert-butyl-4-hydroxy-phenyl)-thiophen-2-yl-methanone
• R-830T
• Prifelonum [INN-Latin]
• Prifelone
• R 830