盐酸利多卡因

• 常用名: 盐酸利多卡因
• 英文名: Lidocaine hydrochloride
• CAS号: 73-78-9
• 分子量: 270.798
• 密度: N/A
• 沸点: 350.8ºC at 760 mmHg
• 分子式: C₁₄H₂₃ClN₂O
• 熔点: 80-82°C
• 闪点: 166ºC

盐酸利多卡因用途

Lidocaine盐酸盐体内体外证实有抗炎症活性,可能和弱化炎症因子和ICAM1有关。

盐酸利多卡因名称

• 中文名: 盐酸利多卡因
• 英文名: lidocaine hydrochloride
• 中文别名: 2-二乙氨基-N-2,6-二甲苯基乙酰胺氮盐酸盐 | 利多卡因盐酸盐 | 克拉维酸锂 | N-(2,6-二甲苯基)-2-(二乙氨基)乙酰胺盐酸盐

盐酸利多卡因生物活性

• 描述: Lidocaine盐酸盐体内体外证实有抗炎症活性,可能和弱化炎症因子和ICAM1有关。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. VAN DER Wal S, et al. Lidocaine increases the anti-inflammatory cytokine IL-10 following mechanical ventilation in healthy mice. Acta Anaesthesiol Scand. 2014 Oct 14.

  [2]. Acevedo-Arcique CM, et al. Lidocaine, dexmedetomidine and their combination reduce isoflurane minimum alveolar concentration in dogs. PLoS One. 2014 Sep 18;9(9):e106620.

盐酸利多卡因物理化学性质

• 沸点: 350.8ºC at 760 mmHg
• 熔点: 80-82°C
• 分子式: C₁₄H₂₃ClN₂O
• 分子量: 270.798
• 闪点: 166ºC
• 精确质量: 270.149902
• PSA: 32.34000
• LogP: 3.45870
• InChIKey: IYBQHJMYDGVZRY-UHFFFAOYSA-N
• SMILES: CCN(CC)CC(=O)Nc1c(C)cccc1C.Cl
• 外观性状: 白色晶体粉末
• 储存条件: Refrigerator
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:2

  3.氢键受体数量:2

  4.可旋转化学键数量:5

  5.互变异构体数量:3

  6.拓扑分子极性表面积32.3

  7.重原子数量:18

  8.表面电荷:0

  9.复杂度:228

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

盐酸利多卡因毒性和生态

盐酸利多卡因安全信息

• 危险品运输编码: 3249
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2924299090

盐酸利多卡因海关

• 海关编码: 2924299090
• 中文概述: 2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 包装
• Summary: 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

盐酸利多卡因靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Validation... 来源：NMMLSC 靶标：ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens] External Id：UNMCMD_ABCB6_1o_ValidationSet

实验名称：Identifying Sarm1 Tir Hydrolase inhibitors through NAD-Glo assay 来源：24386 靶标：N/A External Id：Sarm1 Tir NADase inhibitors screen

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盐酸利多卡因英文别名

• LIDOCAINE HCL
• 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide,hydrochloride
• 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamidhydrochlorid
• Xyloneural
• XYLOCAINE HYDROCHLORIDE
• N-(2,6-Dimethylphenyl)-N,N-diethylglycinamide hydrochloride (1:1)
• MFCD00034865
• (Diethylamino)-2',6'-acetoxylidide Monohydrochloride
• 2-(diéthylamino)-N-(2,6-diméthylphényl)acétamide chlorhydrate
• Xilina hydrochloride
• 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide, hydrochloride (1:1)
• N-(2,6-dimethylphenyl)-N,N-diethylglycinamide hydrochloride
• Lidocaine hydrochloride
• lignocaine hydrochloride
• 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide monohydrochloride
• Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, hydrochloride (1:1)
• Lidocaton
• Lidothesin
• Laryng-O-jet
• N-(2,6-dimethylphenyl)-N2,N2-diethylglycinamide hydrochloride
• 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride
• EINECS 200-803-8
• 2',6'-Acetoxylidide, 2-(diethylamino)-, monohydrochloride (8CI)
• Xylocard
• 2N2&1VMR B1 F1 &&HCl
• Lidocaine (hydrochloride)