d-64131

• 常用名: d-64131
• 英文名: D-64131
• CAS号: 74588-78-6
• 分子量: 251.280
• 密度: 1.2±0.1 g/cm3
• 沸点: 455.2±25.0 °C at 760 mmHg
• 分子式: C₁₆H₁₃NO₂
• 熔点: N/A
• 闪点: 229.1±23.2 °C

d-64131用途

D-64131是微管蛋白聚合抑制剂,能与秋水仙素竞争性结合αβ-微管蛋白。

d-64131名称

• 中文名: d-64131
• 英文名: (5-methoxy-1H-indol-2-yl)-phenylmethanone

d-64131生物活性

• 描述: D-64131是微管蛋白聚合抑制剂,能与秋水仙素竞争性结合αβ-微管蛋白。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Mahboobi, Siavosh; Pongratz, Herwig; Hufsky, Harald et al. Synthetic 2-Aroylindole Derivatives as a New Class of Potent Tubulin-Inhibitory, Antimitotic Agents. Journal of Medicinal Chemistry (2001), 44(26), 4535-4553.

  [2]. Bacher, G.; Beckers, T.; Emig, P. et al. New small-molecule tubulin inhibitors. Pure and Applied Chemistry (2001), 73(9), 1459-1464.

  [3]. Beckers, Thomas; Reissmann, Thomas; Schmidt, Mathias et al. 2-Aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Research (2002), 62(11), 3113-3119.

d-64131物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 455.2±25.0 °C at 760 mmHg
• 分子式: C₁₆H₁₃NO₂
• 分子量: 251.280
• 闪点: 229.1±23.2 °C
• 精确质量: 251.094635
• PSA: 42.09000
• LogP: 2.65
• InChIKey: ICMIJSRDISNKOC-UHFFFAOYSA-N
• SMILES: COc1ccc2[nH]c(C(=O)c3ccccc3)cc2c1
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.657
• 储存条件: 2-8℃

d-64131靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Optimum tumor weight of treated / control animals in % (deviation) for a dose of 100 ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL732699

实验名称：Inhibition of tubulin polymerization. 来源：ChEMBL 靶标：Tubulin beta-2B chain External Id：CHEMBL815034

实验名称：Optimum tumor weight of treated / control animals in % (deviation) for a dose of 200 ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL733311

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Hit confirmation of the active molecules of the enzymatic assay of human HDAC6 with c... 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808151

实验名称：Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with cu... 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808152

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：qHTS for inhibitors of Vif-A3G interactions: Validation 来源：NCGC 靶标：DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] External Id：VIFG001

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d-64131英文别名

• Tocris-1643
• 5-methoxy-2-benzoylindole
• 5-methoxy-1H-2-indolylphenyl-1-methanone
• (5-Methoxy-1H-indol-2-yl)(phenyl)methanone
• D-64131