5-羧酰胺色胺马来酸盐

更新时间：2024-01-03 18:34:57

5-羧酰胺色胺马来酸盐结构式	常用名	5-羧酰胺色胺马来酸盐	英文名	5-Carboxamidotryptamine maleate
	CAS号	74885-72-6	分子量	319.31
	密度	N/A	沸点	N/A
	分子式	C₁₅H₁₇N₃O₅	熔点	N/A
	MSDS	美版	闪点	N/A
	符号	GHS07	信号词	Warning

5-羧酰胺色胺马来酸盐用途

5-Carboxamidotryptamine maleate (5-CT maleate) 是一种有效的 5-HT1A,5-HT1B,5-HT1D,5-HT5 和 5-HT7 受体激动剂。

中文名	5-羧酰胺色胺马来酸盐
英文名	5-Carboxamidotryptamine maleate
英文别名	更多

描述	5-Carboxamidotryptamine maleate (5-CT maleate) 是一种有效的 5-HT1A,5-HT1B,5-HT1D,5-HT5 和 5-HT7 受体激动剂。
相关类别	研究领域 >> 神经疾病信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体信号通路 >> 神经信号通路 >> 5-HT受体
靶点	5-HT1A Receptor 5-HT1B Receptor 5-HT1D Receptor 5-HT5 Receptor 5-HT7 Receptor
体外研究	与牛黑质5-HT1D位点结合的[3H]-5-Carboxamidoryptamine(5-CT)具有快速、可逆和饱和的特点,表现出高亲和力(Kd=0.38nm)和低非特异性结合[2]。在牛黑质中,[3H]-5-甲酰胺三嗪(5-CT)标记的结合位点数量与[3H]-5-Carboxamidoryptamine(分别为403和362fmol/mg蛋白质)的结合位点,并且结合对鸟嘌呤核苷酸敏感[2]。
体内研究	暴露于硬脑膜的外用5-卡波胺(0.01-1000μM)可使麻醉Wistar大鼠的中脑膜动脉舒张压降低,脑膜血流量发生变化,传导率增加(即扩张)(5-羟色胺耗竭,用20 mg/kg皮质酮治疗)[1]。
参考文献	[1]. E Martínez-García, et al. 5-HT7 receptor-mediated meningeal dilatation induced by 5-carboxamidotryptamine in rats is not altered by 5-HT depletion and chronic corticosterone treatment. Proc West Pharmacol Soc. 2011;54:57-61. [2]. H P Nowak, et al. [3H]-5-carboxamidotryptamine labels 5-HT1D binding sites in bovine substantia nigra. Br J Pharmacol. 1993 Aug;109(4):1206-11. [3]. J Yamada, et al. Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats. Eur J Pharmacol. 1998 Oct 16;359(1):81-6.

分子式	C₁₅H₁₇N₃O₅
分子量	319.31
外观性状	固体
储存条件	-20°C

符号	GHS07
信号词	Warning
危害声明	H315-H319-H335
警示性声明	P261-P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xi
危险品运输编码	NONH for all modes of transport

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