阿奇霉素 A结构式
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常用名 | 阿奇霉素 A | 英文名 | Azathramycin |
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CAS号 | 76801-85-9 | 分子量 | 734.958 | |
密度 | 1.2±0.1 g/cm3 | 沸点 | 815.2±65.0 °C at 760 mmHg | |
分子式 | C37H70N2O12 | 熔点 | 126-136ºC | |
MSDS | N/A | 闪点 | 446.8±34.3 °C | |
符号 |
GHS07 |
信号词 | Warning |
阿奇霉素 A用途Azithromycin为抗生素,能与细菌核糖体50S亚基结合,抑制mRNA的翻译。 |
中文名 | 阿奇霉素 A |
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英文名 | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one |
中文别名 | 9-去氧-9a-氮杂-同型红霉素A 去甲阿奇霉素 | 去甲阿奇霉素 | 阿奇霉素杂质 A |
英文别名 | 更多 |
描述 | Azathramycin 是一种抗生素。 |
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相关类别 | |
参考文献 |
[3]. Fernandez-Obregon AC. Azithromycin for the treatment of acne. Int J Dermatol. 2000 Jan;39(1):45-50. |
密度 | 1.2±0.1 g/cm3 |
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沸点 | 815.2±65.0 °C at 760 mmHg |
熔点 | 126-136ºC |
分子式 | C37H70N2O12 |
分子量 | 734.958 |
闪点 | 446.8±34.3 °C |
精确质量 | 734.492859 |
PSA | 188.87000 |
LogP | 3.11 |
外观性状 | 白色固体 |
蒸汽压 | 0.0±0.6 mmHg at 25°C |
折射率 | 1.536 |
储存条件 | -20℃ |
符号 |
GHS07 |
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信号词 | Warning |
危害声明 | H319 |
警示性声明 | P305 + P351 + P338 |
危险品运输编码 | NONH for all modes of transport |
~83% 阿奇霉素 A 76801-85-9 |
文献:ALEMBIC LIMITED Patent: WO2009/156938 A2, 2009 ; Location in patent: Page/Page column 8 ; |
~% 阿奇霉素 A 76801-85-9 |
文献:WO2007/80507 A2, ; Page/Page column 11 ; |
~44% 阿奇霉素 A 76801-85-9 |
文献:Costa, Anna M.; Vilarrasa, Jaume Tetrahedron Letters, 2000 , vol. 41, # 18 p. 3371 - 3375 |
~% 阿奇霉素 A 76801-85-9 |
文献:Lee, Younjoo; Choi, Jun Yong; Fu, Hong; Harvey, Colin; Ravindran, Sandeep; Roush, William R.; Boothroyd, John C.; Khosla, Chaitan Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 2792 - 2804 |
~% 阿奇霉素 A 76801-85-9 |
文献:Journal of Medicinal Chemistry, , vol. 54, # 8 p. 2792 - 2804 |
阿奇霉素 A上游产品 3 | |
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阿奇霉素 A下游产品 1 | |
Peptide-mediated macrolide resistance reveals possible specific interactions in the nascent peptide exit tunnel.
Mol. Microbiol. 54(2) , 376-85, (2004) Expression of specific short peptides can render cells resistant to macrolide antibiotics. Peptides conferring resistance to structurally different macrolides including oleandomycin, azithromycin, aza... |
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Quantitative thin-layer chromatographic method of analysis of azithromycin in pure and capsule forms.
J. Chromatogr. Sci. 41(1) , 10-6, (2003) A validated stability-indicating thin-layer chromatographic (TLC) method of the analysis of azithromycin (AZT) in bulk and capsule forms is developed. Both AZT potential impurity and degradation produ... |
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Erythromycin series. XII. Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A: synthesis and structure-activity relationship of its acyl derivatives.
J. Antibiot. 40(7) , 1006-15, (1987) Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A (5), the new 15-membered semi-synthetic macrolide antibiotic with nitrogen as additional atom in the aglycone ring of eryt... |
9-deokso-9a-aza-9a-homoeritromicin A |
Desmethylazithromycin |
1-oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)- |
9a-N-desmethyl azithromycin |
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2, 6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside |
DD-Azaerythromycin A |
10-Dihydro-10-deoxo-11-azaerythromycin A |
9-Deoxo-9a-aza-9a-homo Erythromycin A(Desmethyl Azithromycin) |
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside |
9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin A |
9a-aza-9-deoxo-9a-homoerythromycin A |
9-deoxo-9a-aza-9a-homoerythromycin |
Azaerythromycin A |
UNII-4LSP9FJT5B |
1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β -D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)- |
9-deoxo-9a-aza-9a-homoerythromycin A |
Azathramycin |