阿奇霉素 A

更新时间:2024-01-02 09:47:35

阿奇霉素 A结构式
阿奇霉素 A结构式
品牌特惠专场
常用名 阿奇霉素 A 英文名 Azathramycin
CAS号 76801-85-9 分子量 734.958
密度 1.2±0.1 g/cm3 沸点 815.2±65.0 °C at 760 mmHg
分子式 C37H70N2O12 熔点 126-136ºC
MSDS N/A 闪点 446.8±34.3 °C
符号 GHS07
GHS07
信号词 Warning

 阿奇霉素 A用途


Azithromycin为抗生素,能与细菌核糖体50S亚基结合,抑制mRNA的翻译。

 阿奇霉素 A名称

中文名 阿奇霉素 A
英文名 (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
中文别名 9-去氧-9a-氮杂-同型红霉素A 去甲阿奇霉素 | 去甲阿奇霉素 | 阿奇霉素杂质 A
英文别名 更多

 阿奇霉素 A物理化学性质

密度 1.2±0.1 g/cm3
沸点 815.2±65.0 °C at 760 mmHg
熔点 126-136ºC
分子式 C37H70N2O12
分子量 734.958
闪点 446.8±34.3 °C
精确质量 734.492859
PSA 188.87000
LogP 3.11
外观性状 白色固体
蒸汽压 0.0±0.6 mmHg at 25°C
折射率 1.536
储存条件 -20℃

 阿奇霉素 A安全信息

符号 GHS07
GHS07
信号词 Warning
危害声明 H319
警示性声明 P305 + P351 + P338
危险品运输编码 NONH for all modes of transport

 阿奇霉素 A合成线路

~83%

阿奇霉素 A结构式

阿奇霉素 A

76801-85-9

文献:ALEMBIC LIMITED Patent: WO2009/156938 A2, 2009 ; Location in patent: Page/Page column 8 ;

~%

阿奇霉素 A结构式

阿奇霉素 A

76801-85-9

文献:WO2007/80507 A2, ; Page/Page column 11 ;

~44%

阿奇霉素 A结构式

阿奇霉素 A

76801-85-9

文献:Costa, Anna M.; Vilarrasa, Jaume Tetrahedron Letters, 2000 , vol. 41, # 18 p. 3371 - 3375

~%

阿奇霉素 A结构式

阿奇霉素 A

76801-85-9

文献:Lee, Younjoo; Choi, Jun Yong; Fu, Hong; Harvey, Colin; Ravindran, Sandeep; Roush, William R.; Boothroyd, John C.; Khosla, Chaitan Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 2792 - 2804

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阿奇霉素 A结构式

阿奇霉素 A

76801-85-9

文献:Journal of Medicinal Chemistry, , vol. 54, # 8 p. 2792 - 2804

 阿奇霉素 A上下游产品

阿奇霉素 A上游产品  3

阿奇霉素 A下游产品  1

 阿奇霉素 A文献3

更多文献
Peptide-mediated macrolide resistance reveals possible specific interactions in the nascent peptide exit tunnel.

Mol. Microbiol. 54(2) , 376-85, (2004)

Expression of specific short peptides can render cells resistant to macrolide antibiotics. Peptides conferring resistance to structurally different macrolides including oleandomycin, azithromycin, aza...

Quantitative thin-layer chromatographic method of analysis of azithromycin in pure and capsule forms.

J. Chromatogr. Sci. 41(1) , 10-6, (2003)

A validated stability-indicating thin-layer chromatographic (TLC) method of the analysis of azithromycin (AZT) in bulk and capsule forms is developed. Both AZT potential impurity and degradation produ...

Erythromycin series. XII. Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A: synthesis and structure-activity relationship of its acyl derivatives.

J. Antibiot. 40(7) , 1006-15, (1987)

Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A (5), the new 15-membered semi-synthetic macrolide antibiotic with nitrogen as additional atom in the aglycone ring of eryt...

 阿奇霉素 A英文别名

9-deokso-9a-aza-9a-homoeritromicin A
Desmethylazithromycin
1-oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
9a-N-desmethyl azithromycin
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2, 6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside
DD-Azaerythromycin A
10-Dihydro-10-deoxo-11-azaerythromycin A
9-Deoxo-9a-aza-9a-homo Erythromycin A(Desmethyl Azithromycin)
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside
9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin A
9a-aza-9-deoxo-9a-homoerythromycin A
9-deoxo-9a-aza-9a-homoerythromycin
Azaerythromycin A
UNII-4LSP9FJT5B
1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β -D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
9-deoxo-9a-aza-9a-homoerythromycin A
Azathramycin
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