呋拉茶碱

更新时间：2025-09-10 09:40:38

呋拉茶碱结构式	常用名	呋拉茶碱	英文名	Furafylline
	CAS号	80288-49-9	分子量	260.249
	密度	1.4±0.1 g/cm3	沸点	543.6±60.0 °C at 760 mmHg
	分子式	C₁₂H₁₂N₄O₃	熔点	N/A
	MSDS	中文版美版	闪点	282.6±32.9 °C

呋拉茶碱用途

Furafylline 是一种有效且有选择性的人细胞色素 P450IA2 抑制剂,其 IC50 值为 0.07 μM。

中文名	呋喃茶碱
英文名	3-(furan-2-ylmethyl)-1,8-dimethyl-7H-purine-2,6-dione
中文别名	3-(2-呋喃基甲基)-3,7-二氢-1,8-二甲基-1H-嘌呤-2,6-二酮 \| 呋拉茶碱 \| 呋喃菲林
英文别名	更多

描述	Furafylline 是一种有效且有选择性的人细胞色素 P450IA2 抑制剂,其 IC50 值为 0.07 μM。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450 研究领域 >> 癌症
靶点实验	IC50: 0.07 μM (human cytochrome P450IA2)[1]
体内研究	Furafylline是一种有效的选择性人细胞色素P450IA2抑制剂,在激酶实验中IC50为0.07μM。呋喃茶碱是甲基黄嘌呤衍生物,作为茶碱的长效替代物用于治疗哮喘。由于抑制咖啡因氧化,由一种或多种P450的烃诱导型同工酶催化的反应,呋喃茶碱的施用与咖啡因的血浆水平升高有关。呋喃茶碱对P450的其他同工酶催化的人体单加氧酶活性影响很小或没有影响,包括P4501ID1,P4501IC,P450IIIA [1]。
参考文献	[1]. Sesardic D, et al. Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man. Br J Clin Pharmacol. 1990 Jun;29(6):651-63.

密度	1.4±0.1 g/cm3
沸点	543.6±60.0 °C at 760 mmHg
分子式	C₁₂H₁₂N₄O₃
分子量	260.249
闪点	282.6±32.9 °C
精确质量	260.090942
PSA	85.82000
LogP	-0.24
蒸汽压	0.0±1.5 mmHg at 25°C
折射率	1.637
储存条件	2-8℃

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
WGK德国	3
海关编码	2939590000

海关编码	2939590000

Physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity.

Expert Opin. Drug Metab. Toxicol. 10(10) , 1313-24, (2014)

Drug resistance by Plasmodium falciparum remains a challenge in malaria chemotherapy. This paper will focus on physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hy...

The cytochrome P450-catalyzed metabolism of levomepromazine: a phenothiazine neuroleptic with a wide spectrum of clinical application.

Biochem. Pharmacol. 90(2) , 188-95, (2014)

The aim of the present study was to identify cytochrome P450 isoenzymes (CYPs) involved in the 5-sulfoxidation and N-demethylation of the aliphatic-type phenothiazine neuroleptic levomepromazine in hu...

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Drug Metab. Dispos. 38(1) , 92-9, (2010)

The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite...

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来源：ChEMBL
靶标：N/A
External Id：CHEMBL1266185

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来源：NCGC
External Id：SNCA-p-activity-luciferase

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External Id：CYP273

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来源：ChEMBL
靶标：Cytochrome P450 1A2
External Id：CHEMBL1664602

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来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：Burkholderia multivorans
External Id：HMS1625

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来源：Center for Chemical Genomics, University of Michigan
靶标：N/A
External Id：TargetID_659_CEMA

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来源：824
靶标：N/A
External Id：P53600

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来源：824
靶标：N/A
External Id：P53MS958

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来源：824
External Id：P53MS482

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External Id：P53344

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