Resolvin D2

• 常用名: Resolvin D2
• 英文名: Resolvin D2
• CAS号: 810668-37-2
• 分子量: 376.487
• 密度: 1.1±0.1 g/cm3
• 沸点: 609.2±55.0 °C at 760 mmHg
• 分子式: C₂₂H₃₂O₅
• 熔点: N/A
• 闪点: 336.3±28.0 °C

Resolvin D2用途

Resolvin D2 是 DHA 的代谢物,具有抗炎和抗感染活性。Resolvin D2 是一种高效的白细胞调节器,能控制微生物败血症。在原代感觉神经元中,Resolvin D2 是 TRPV1 (IC50 = 0.1 nM) 和 TRPA1 (IC50 = 2 nM) 的有效抑制剂。

Resolvin D2名称

• 英文名: Resolvin D2

Resolvin D2生物活性

• 描述: Resolvin D2 是 DHA 的代谢物,具有抗炎和抗感染活性。Resolvin D2 是一种高效的白细胞调节器,能控制微生物败血症。在原代感觉神经元中,Resolvin D2 是 TRPV1 (IC50 = 0.1 nM) 和 TRPA1 (IC50 = 2 nM) 的有效抑制剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 感染
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 靶点实验:

  TRP Channel[3]

• 体内研究: Resolvin D2在根管感染后通过牙髓样组织再生诱导炎症的主动消退,因此可能适合治疗根尖周病变[1]。Delvin D2降低白细胞：内皮依赖性一氧化氮产生和内皮细胞相互作用的直接调节,白细胞粘附受体表达的直接调节[2 ]。外周注射Resolvin D2(10 ng；植物内注射)可有效抑制炎症性疼痛[3]。动物模型：成年CD1小鼠(雄性,8-10周)[3]剂量：10ng给药：腹腔给药结果：抑制炎性疼痛。
• 参考文献:

  [1]. Siddiqui YD, et al. Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis. Front Immunol. 2019 Feb 26;10:307.

  [2]. Spite M, et al. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature. 2009 Oct 29;461(7268):1287-91.

  [3]. Park CK, et al. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.6. J Neurosci. 2011 Dec 14;31(50):18433-8.

Resolvin D2物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 609.2±55.0 °C at 760 mmHg
• 分子式: C₂₂H₃₂O₅
• 分子量: 376.487
• 闪点: 336.3±28.0 °C
• 精确质量: 376.224976
• PSA: 97.99000
• LogP: 2.70
• InChIKey: IKFAUGXNBOBQDM-XFMPMKITSA-N
• SMILES: CCC=CCC(O)C(O)C=CC=CC=CC=CC(O)CC=CCCC(=O)O
• 蒸汽压: 0.0±4.0 mmHg at 25°C
• 折射率: 1.559
• 储存条件: -20°C，密闭，干燥

Resolvin D2靶点实验

查看更多实验

实验名称：Agonist activity at mouse GPR18 expressed in CHO cells assessed as activation by meas... 来源：ChEMBL 靶标：N-arachidonyl glycine receptor External Id：CHEMBL5504236

实验名称：Agonist activity at mouse GPR18 expressed in CHO cells assessed as activation by meas... 来源：ChEMBL 靶标：N-arachidonyl glycine receptor External Id：CHEMBL5504235

实验名称：Agonist activity at human GPR18 expressed in CHO cells assessed as activation by meas... 来源：ChEMBL 靶标：N-arachidonyl glycine receptor External Id：CHEMBL5504233

实验名称：Agonist activity at human GPR18 expressed in CHO cells assessed as activation by meas... 来源：ChEMBL 靶标：N-arachidonyl glycine receptor External Id：CHEMBL5504232

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Resolvin D2英文别名

• Resolvin D2
• (4Z,7S,8E,10Z,12E,14E,16R,17S,19Z)-7,16,17-Trihydroxy-4,8,10,12,14,19-docosahexaenoic acid