藁本内酯

• 常用名: 藁本内酯
• 英文名: Z-Ligustilide
• CAS号: 81944-09-4
• 分子量: 190.238
• 密度: 1.1±0.1 g/cm3
• 沸点: 377.9±11.0 °C at 760 mmHg
• 分子式: C₁₂H₁₄O₂
• 熔点: 168～169℃
• 闪点: 158.6±16.7 °C

藁本内酯用途

(Z)-Ligustilide 是从 Ligusticum chuanxiong Hort 中提取的,具有抗菌和抗真菌活性,抗真菌评分为 5.6。(Z)-Ligustilide 抑制 FATP5 和 DGAT 的表达,抑制小鼠脂肪酸的摄取和酯化,具有治疗非酒精性脂肪性肝病 (NAFLD) 的潜力。

藁本内酯名称

• 中文名: 藁本内酯
• 英文名: Ligustilide
• 中文别名: Z-藳本内酯 | 蒿本内酯 A

藁本内酯生物活性

• 描述: (Z)-Ligustilide 是从 Ligusticum chuanxiong Hort 中提取的,具有抗菌和抗真菌活性,抗真菌评分为 5.6。(Z)-Ligustilide 抑制 FATP5 和 DGAT 的表达,抑制小鼠脂肪酸的摄取和酯化,具有治疗非酒精性脂肪性肝病 (NAFLD) 的潜力。
• 相关类别:
  研究领域 >> 感染
  研究领域 >> 代谢疾病
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Rodrigues AMS, et al. The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach. Sci Rep. 2019 Jun 19;9(1):8729. doi: 10.1038/s41598-019-45222-y

  [2]. Ma H, et al. Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa. Oncotarget. 2017 Apr 25;8(17):29328-29345.

藁本内酯物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 377.9±11.0 °C at 760 mmHg
• 熔点: 168～169℃
• 分子式: C₁₂H₁₄O₂
• 分子量: 190.238
• 闪点: 158.6±16.7 °C
• 精确质量: 190.099380
• PSA: 26.30000
• LogP: 2.63
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.545
• 储存条件: 2~8°C

藁本内酯安全信息

• 危害码 (欧洲): Xi

藁本内酯靶点实验

查看更多实验

实验名称：The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre... 来源：11924 靶标：N/A External Id：CGM data for Cell Systems paper Dec 2015

实验名称：Screen for inhibitors of RMI FANCM (MM2) intereaction 来源：11908 靶标：N/A External Id：RMI-FANCM-MM2

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Primary high throughput screening by co-culture imaging for identification hits as a ... 来源：23209 靶标：N/A External Id：UIHTS20180925

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Relative toxicity, LD50 for rotenone Drosophila melanogaster adulticidal activity to ... 来源：ChEMBL 靶标：Drosophila melanogaster External Id：CHEMBL3066384

实验名称：Insecticidal activity against 5 to 7 days old adult Drosophila melanogaster assessed ... 来源：ChEMBL 靶标：Drosophila melanogaster External Id：CHEMBL3066385

实验名称：Feeding deterrent activity against Anopheles stephensi assessed as proportion of mosq... 来源：ChEMBL 靶标：Anopheles stephensi External Id：CHEMBL3050586

实验名称：Feeding deterrent activity against Aedes aegypti liverpool assessed as proportion of ... 来源：ChEMBL 靶标：Aedes aegypti External Id：CHEMBL3050587

实验名称：Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimo... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B1 External Id：CHEMBL3039488

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藁本内酯英文别名

• Ligustilide A
• Ligustilide
• cis-ligustilide
• Z-LIGUSTILIDE
• (3Z)-3-Butylidene-4,5-dihydro-2-benzofuran-1(3H)-one