Z-Ligustilide

Modify Date: 2024-01-02 12:15:24

Z-Ligustilide structure	Common Name	Z-Ligustilide
	CAS Number	81944-09-4	Molecular Weight	190.238
	Density	1.1±0.1 g/cm3	Boiling Point	377.9±11.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₄O₂	Melting Point	168～169℃
	MSDS	N/A	Flash Point	158.6±16.7 °C

Use of Z-Ligustilide

(Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6[1].(Z)-Ligustilide inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) [2].

Name	Ligustilide
Synonym	More Synonyms

Description	(Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6[1].(Z)-Ligustilide inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) [2].
Related Catalog	Research Areas >> Infection Research Areas >> Metabolic Disease Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Rodrigues AMS, et al. The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach. Sci Rep. 2019 Jun 19;9(1):8729. doi: 10.1038/s41598-019-45222-y [2]. Ma H, et al. Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa. Oncotarget. 2017 Apr 25;8(17):29328-29345.

Description

Related Catalog

Research Areas >> Infection

Research Areas >> Metabolic Disease

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. Rodrigues AMS, et al. The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach. Sci Rep. 2019 Jun 19;9(1):8729. doi: 10.1038/s41598-019-45222-y

[2]. Ma H, et al. Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa. Oncotarget. 2017 Apr 25;8(17):29328-29345.

Density	1.1±0.1 g/cm3
Boiling Point	377.9±11.0 °C at 760 mmHg
Melting Point	168～169℃
Molecular Formula	C₁₂H₁₄O₂
Molecular Weight	190.238
Flash Point	158.6±16.7 °C
Exact Mass	190.099380
PSA	26.30000
LogP	2.63
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.545
Storage condition	2~8°C