TC-E 5001

• 常用名: TC-E 5001
• 英文名: TC-E 5001
• CAS号: 865565-29-3
• 分子量: 409.46
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₉N₅O₃S
• 熔点: N/A
• 闪点: N/A

TC-E 5001用途

TC-E 5001是Wnt途径的抑制剂,通过新的腺苷囊结合抑制tankyrase 1/2(TNKS1/2),Kds分别为79 nM和28 nM。TC-E 5001还抑制Axin2和STF,IC50分别为0.709μM和0.215μM[1][2]。

TC-E 5001名称

• 英文名: 3-(4-methoxyphenyl)-5-(((4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl)thio)methyl)-1,2,4-oxadiazole

TC-E 5001生物活性

• 描述: TC-E 5001是Wnt途径的抑制剂,通过新的腺苷囊结合抑制tankyrase 1/2(TNKS1/2),Kds分别为79 nM和28 nM。TC-E 5001还抑制Axin2和STF,IC50分别为0.709μM和0.215μM[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> PARP
  信号通路 >> 细胞周期/DNA损伤 >> PARP
• 靶点实验:

  TNKS1:79 nM (Ki)

  TNKS2:28 nM (Ki)

• 体外研究: TC-E 5001抑制TNKS2,IC50为33 nM[1]。
• 参考文献:

  [1]. Shultz MD, et, al. [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J Med Chem. 2012 Feb 9;55(3):1127-36.

  [2]. Lien VT, et, al. Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation. RSC Advances. 2019 Jour; 9(63): 37092-37100.

TC-E 5001物理化学性质

• 分子式: C₂₀H₁₉N₅O₃S
• 分子量: 409.46
• 精确质量: 409.12100
• PSA: 113.39000
• LogP: 3.93520
• InChIKey: LQZSHPITKSPDLC-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2noc(CSc3nnc(C)n3-c3ccc(OC)cc3)n2)cc1
• 储存条件: 2-8°C，干燥，密封

TC-E 5001安全信息

• 危害码 (欧洲): Xi

TC-E 5001靶点实验

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