TC-E 5001
Modify Date: 2025-09-18 18:35:24
TC-E 5001 structure
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Common Name | TC-E 5001 | ||
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| CAS Number | 865565-29-3 | Molecular Weight | 409.46 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H19N5O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TC-E 5001TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively[1][2]. |
| Name | 3-(4-methoxyphenyl)-5-(((4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl)thio)methyl)-1,2,4-oxadiazole |
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| Description | TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively[1][2]. |
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| Related Catalog | |
| Target |
TNKS1:79 nM (Ki) TNKS2:28 nM (Ki) |
| In Vitro | TC-E 5001 inhibits TNKS2, with an IC50 of 33 nM[1]. |
| References |
| Molecular Formula | C20H19N5O3S |
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| Molecular Weight | 409.46 |
| Exact Mass | 409.12100 |
| PSA | 113.39000 |
| LogP | 3.93520 |
| Hazard Codes | Xi |
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