Rifaquizinone

更新时间：2024-01-02 21:09:57

Rifaquizinone结构式	常用名	Rifaquizinone	英文名	Rifaquizinone
	CAS号	922717-97-3	分子量	1205.37
	密度	1.4±0.1 g/cm3	沸点	N/A
	分子式	C₆₅H₈₁FN₆O₁₅	熔点	N/A
	MSDS	N/A	闪点	N/A

Rifaquizinone用途

本网站展示的所有产品仅用作科学研究，不可食用，不可用于人体或动物的临床诊断和治疗。

Rifaquizinone (CBR-2092) 是一种利福霉素-喹诺酮混合抗生素。Rifaquizinone 抑制野生型金黄色葡萄球菌 RNA 聚合酶,IC50 为 34 nM。Rifaquizinone 有效抑制金黄色葡萄球菌感染,对 300 种葡萄球菌和链球菌临床分离株的 MIC 范围为 0.008-0.5 μg/mL。

英文名	8-[(3R)-3-{1-[{1-[(E)-{[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-13-Acetoxy-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-26-yl]methylene}amino]-4-piperidinyl}(methyl)amino]cyclopropyl}-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid
英文别名	更多

英文名

8-[(3R)-3-{1-[{1-[(E)-{[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-13-Acetoxy-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-26-yl]methylene}amino]-4-piperidinyl}(methyl)amino]cyclopropyl}-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid

英文别名

描述	Rifaquizinone (CBR-2092) 是一种利福霉素-喹诺酮混合抗生素。Rifaquizinone 抑制野生型金黄色葡萄球菌 RNA 聚合酶,IC50 为 34 nM。Rifaquizinone 有效抑制金黄色葡萄球菌感染,对 300 种葡萄球菌和链球菌临床分离株的 MIC 范围为 0.008-0.5 μg/mL。
相关类别	研究领域 >> 感染信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成信号通路 >> 抗感染 >> 细菌
参考文献	[1]. Robertson GT, et al. In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus. Antimicrob Agents Chemother. 2008 Jul;52(7):2313-23. [2]. Robertson GT, et al. In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: microbiology profiling studies with staphylococci and streptococci. Antimicrob Agents Chemother. 2008 Jul;52(7):2324-34.

描述

相关类别

研究领域 >> 感染

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

信号通路 >> 抗感染 >> 细菌

参考文献

[1]. Robertson GT, et al. In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus. Antimicrob Agents Chemother. 2008 Jul;52(7):2313-23.

[2]. Robertson GT, et al. In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: microbiology profiling studies with staphylococci and streptococci. Antimicrob Agents Chemother. 2008 Jul;52(7):2324-34.

密度	1.4±0.1 g/cm3
分子式	C₆₅H₈₁FN₆O₁₅
分子量	1205.37
精确质量	1204.574341
LogP	3.56
折射率	1.665

8-[(3R)-3-{1-[{1-[(E)-{[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-13-Acetoxy-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1 4,7.05,28]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-26-yl]methylene}amino]-4-piperidinyl}(methyl)amino]cyclopropyl}-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxy lic acid

4H-Quinolizine-3-carboxylic acid, 8-[(3R)-3-[1-[[1-[[(1E)-[(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(acetyloxy)-1,2-dihydro-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxy[1,11,13]pentadecatrienoimino)naphtho[2,1-b]furan-8-yl]methylene]amino]-4-piperidinyl]methylamino]cyclopropyl]-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-

Rifaquizinone

Rifaquizinone用途

Rifaquizinone名称

Rifaquizinone生物活性

Rifaquizinone物理化学性质

Rifaquizinone英文别名