(3R,5S)-氟丁他汀钠盐

• 常用名: (3R,5S)-氟丁他汀钠盐
• 英文名: SRI 62320
• CAS号: 94061-80-0
• 分子量: 433.45
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₅FNNaO₄
• 熔点: N/A
• 闪点: N/A

(3R,5S)-氟丁他汀钠盐用途

(3R,5S)-Fluvastatin ((3R,5S)-XU 62-320) sodium 是 Fluvastatin 的 3R,5S-异构体。Fluvastatin (XU 62-320 free acid) 是第一个完全合成的,竞争性的 HMG-CoA 还原酶抑制剂,IC50 为 8 nM。Fluvastatin 通过依赖 Nrf2 的抗氧化通路保护血管平滑肌细胞免受氧化应激。

(3R,5S)-氟丁他汀钠盐名称

• 中文名: (3R,5S)-氟丁他汀钠盐
• 英文名: sodium,(E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate

(3R,5S)-氟丁他汀钠盐生物活性

• 描述: (3R,5S)-Fluvastatin ((3R,5S)-XU 62-320) sodium 是 Fluvastatin 的 3R,5S-异构体。Fluvastatin (XU 62-320 free acid) 是第一个完全合成的,竞争性的 HMG-CoA 还原酶抑制剂,IC50 为 8 nM。Fluvastatin 通过依赖 Nrf2 的抗氧化通路保护血管平滑肌细胞免受氧化应激。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
  信号通路 >> 自噬 >> 自噬
• 参考文献:

  [1]. Araújo FA, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24.

  [2]. Makabe S, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84.

(3R,5S)-氟丁他汀钠盐物理化学性质

• 分子式: C₂₄H₂₅FNNaO₄
• 分子量: 433.45
• 精确质量: 433.16700
• PSA: 85.52000
• LogP: 3.29340
• InChIKey: ZGGHKIMDNBDHJB-NRFPMOEYSA-M
• SMILES: CC(C)n1c(C=CC(O)CC(O)CC(=O)[O-])c(-c2ccc(F)cc2)c2ccccc21.[Na+]

(3R,5S)-氟丁他汀钠盐靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Incorporation of [14C]- acetate into sterols measured in rat liver. 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL779600

实验名称：Incorporation of [14C]- acetate into sterols measured in rat spleen. 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL779601

实验名称：Incorporation of [14C]- acetate into sterols measured in rat testis. 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL779602

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity 来源：NCGC External Id：HERG01

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

实验名称：uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay 来源：Burnham Center for Chemical Genomics 靶标：cystic fibrosis transmembrane conductance regulator [Homo sapiens] External Id：SBCCG-A764-CF-PAF-Primary-Assay

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(3R,5S)-氟丁他汀钠盐英文别名

• (3R,5S)-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic acid monosodium salt
• Canef
• FLUVASTATIN SODIUM
• (+)-(3R,5S)-fluvastatin sodium
• (3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid sodium salt
• XU-62-320
• Lescol
• fluindostatin
• (E)-(3R,5S)-(+)-7-[3-(4-fluoro-phenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxy-hept-6-enoic acid sodium salt
• erythro-(E)-3R,5S-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid,sodium salt