ALX-1393

• 常用名: ALX-1393
• 英文名: ALX-1393
• CAS号: 949164-09-4
• 分子量: 395.42300
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₂FNO₄
• 熔点: N/A
• 闪点: N/A

ALX-1393用途

ALX-1393 是一种选择性 GlyT2 抑制剂, 对大鼠急性疼痛模型中的热,机械和化学刺激具有抗伤害作用。

ALX-1393名称

• 英文名: O-[(2-benzyloxyphenyl)(3-fluorophenyl)methyl]-L-serine

ALX-1393生物活性

• 描述: ALX-1393 是一种选择性 GlyT2 抑制剂, 对大鼠急性疼痛模型中的热,机械和化学刺激具有抗伤害作用。
• 相关类别:
  信号通路 >> 跨膜转运 >> GLYT
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> GLYT
• 靶点实验:

  GlyT2[1]

• 体内研究: 正常大鼠的ALX1393(i.c.v.; 25,50和100μg)抑制福尔马林试验中的晚期反应,但不影响运动性能。ALX1393以剂量依赖性方式抑制机械和冷痛觉过敏[2]。
• 参考文献:

  [1]. Haranishi Y, et al. The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model. Anesth Analg. 2010 Feb 1;110(2):615-21.

  [2]. Takahashi Y, et al. Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain. Pharmacol Biochem Behav. 2015 Mar;130:46-52.

ALX-1393物理化学性质

• 分子式: C₂₃H₂₂FNO₄
• 分子量: 395.42300
• 精确质量: 395.15300
• PSA: 81.78000
• LogP: 4.62290
• InChIKey: ADUSZEGHFWRTQS-PSDZMVHGSA-N
• SMILES: NC(COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(=O)O
• 储存条件: 2-8°C，密封，干燥

ALX-1393靶点实验

查看更多实验

实验名称：Unbound brain to plasma concentration ratio in mouse 来源：ChEMBL 靶标：N/A External Id：CHEMBL4219904

实验名称：Selectivity ratio of IC50 for human GlyT-1 expressed in HEK293 cells to IC50 for huma... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4219903

实验名称：Inhibition of human GlyT2 expressed in porcine aorta epithelial cells assessed as red... 来源：ChEMBL 靶标：Sodium- and chloride-dependent glycine transporter 2 External Id：CHEMBL4434264

实验名称：Antiallodynic activity in spinal cord injury Sprague-Dawley rat model assessed as inh... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4219912

实验名称：Antiallodynic activity in spinal cord injury Sprague-Dawley rat model assessed as inh... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4219911

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：qHTS for Inhibitors of binding or entry into cells for Marburg Virus 来源：NCGC 靶标：gene 4 small orf - Marburg virus External Id：VSVM-OFFLINE

实验名称：Antiallodynic activity in spinal cord injury Sprague-Dawley rat model assessed as inh... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4219910

实验名称：qHTS for Inhibitors of binding or entry into cells for Lassa Virus 来源：NCGC 靶标：N/A External Id：VSVL-OFFLINE

实验名称：Antiallodynic activity in spinal cord injury Sprague-Dawley rat model assessed as inh... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4219909

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