Flupyradifurone

• 常用名: Flupyradifurone
• 英文名: Flupyradifurone
• CAS号: 951659-40-8
• 分子量: 288.67800
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₁₁ClF₂N₂O₂
• 熔点: 69°C(lit.)
• 闪点: N/A

Flupyradifurone用途

氟吡呋酮是一种内吸性杀虫剂,属于丁烯内酯类杀虫剂,可用于农业目的,以控制各种吸吮性昆虫。氟吡呋喃酮含有特殊的药效基团丁烯酸内酯,因此具有较好的内吸传导性,叶面喷施或进行种子处理后,能迅速传导至植株各部位,可有效防治叶面背部或隐蔽取食的害虫,并能通过抑制昆虫的摄食,进而减少依赖昆虫介导的病原体传播。

Flupyradifurone名称

• 中文名: 氟哌啶酮
• 英文名: flupyradifurone

Flupyradifurone生物活性

• 描述: 氟吡呋喃酮是一种全身性nAChR激动剂,可干扰吸食害虫中枢神经系统的信号转导。氟吡呋喃酮可用作丁烯内酯类杀虫剂[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 跨膜转运 >> 胆碱受体
  信号通路 >> 神经信号通路 >> 胆碱受体
• 体外研究: 氟吡呋喃酮是一种丁烯内酯类杀虫剂,可激活昆虫NACHR。氟吡呋喃酮是一种丁烯内酯类杀虫剂,被认为对蜜蜂健康有益[1]。杀虫剂氟吡呋喃酮(FLF)与吡虫啉(IMI)竞争昆虫nAChR上相同的高亲和力结合位点,其调节导致毒性终点[2]。
• 体内研究: 辣椒中氟吡呋喃酮的半衰期为2.6-3.8天。全国氟吡呋喃酮的估计每日摄入量为0.00094 mg/kg[3]。
• 参考文献:

  [1]. Yi Guo, et al. The Effects of Exposure to Flupyradifurone on Survival, Development, and Foraging Activity of Honey Bees (Apis mellifera L.) under Field Conditions. Insects. 2021 Apr 16;12(4):357.

  [2]. Mark Montgomery, et al. Structural Biology-Guided Design, Synthesis, and Biological Evaluation of Novel Insect Nicotinic Acetylcholine Receptor Orthosteric Modulators. J Med Chem. 2022 Jan 5.

  [3]. Yizhi Feng, et al. Determination, residue analysis, dietary risk assessment, and processing of flupyradifurone and its metabolites in pepper under field conditions using LC-MS/MS. Biomed Chromatogr. 2022 Jan 3;e5312.

Flupyradifurone物理化学性质

• 熔点: 69°C(lit.)
• 分子式: C₁₂H₁₁ClF₂N₂O₂
• 分子量: 288.67800
• 精确质量: 288.04800
• PSA: 42.43000
• LogP: 2.24280
• InChIKey: QOIYTRGFOFZNKF-UHFFFAOYSA-N
• SMILES: O=C1C=C(N(Cc2ccc(Cl)nc2)CC(F)F)CO1
• 外观性状: 结晶
• 储存条件: 室温

FlupyradifuroneMSDS

FlupyradifuroneMSDS英文版

Flupyradifurone安全信息

• 危害码 (欧洲): Xn

Flupyradifurone靶点实验

查看更多实验

实验名称：Toxicity in Aphis gossypii assessed as mortality at 4 mg/L relative to control 来源：ChEMBL 靶标：N/A External Id：CHEMBL5105290

实验名称：Toxicity in Aphis craccivora assessed as mortality at 100 mg/ml relative to control 来源：ChEMBL 靶标：N/A External Id：CHEMBL5105286

实验名称：Toxicity in Nilaparvata lugens assessed as mortality at 100 mg/ml relative to control 来源：ChEMBL 靶标：N/A External Id：CHEMBL5105287

实验名称：Toxicity in Anopheles darlingi larvae measured after 48 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL5105288

实验名称：Toxicity in Myzus persicae assessed as mortality at 0.80 mg/L relative to control 来源：ChEMBL 靶标：N/A External Id：CHEMBL5105289

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Flupyradifurone英文别名

• 4-[(6-chloro-3-pyridylmethyl)(2,2-difluoroethyl)amino]furan-2(5H)-one
• 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluoro-ethyl)amino}furan-2(5H)-one
• 4-{[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one
• Flupyradifurone [ISO]
• 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluorethyl)amino}furan-2(5H)-one
• 4-[[(6-chloro-3-pyridinyl)methyl](2,2-difluoroethyl)amino]-2(5H)-furanone
• 3-[(6-chloropyridin-3-yl)-(2,2-difluoroethyl)amino]-2H-furan-5-one