DY131

• 常用名: DY131
• 英文名: DY131
• CAS号: 95167-41-2
• 分子量: 311.378
• 密度: 1.1±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₈H₂₁N₃O₂
• 熔点: N/A
• 闪点: N/A

DY131用途

DY131(GSK 9089)是ERRβ和ERRγ选择性激动剂,对ERRα,ERα和ERβ的活性极低。

DY131名称

• 中文名: DY131
• 英文名: DY131

DY131生物活性

• 描述: DY131(GSK 9089)是ERRβ和ERRγ选择性激动剂,对ERRα,ERα和ERβ的活性极低。
• 相关类别:
  信号通路 >> 其他 >> 雌激素受体/ERR
  研究领域 >> 癌症
• 参考文献:

  [1]. Wang Y, Arvanites AC, Davidow L,et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation . ACS Chem Biol. 2012,15;7(6):1040-8.

  [2]. Kumar P, Mendelson CR. Estrogen-related receptor gamma (ERRgamma) mediates oxygen-dependent induction of aromatase (CYP19) gene expression during human trophoblast differentiation. Mol Endocrinol. 2011;25(9):1513-26.

  [3]. Yamamoto T, Mori T, Sawada M, et al. Estrogen-related receptor-γ regulates estrogen receptor-α responsiveness in uterine endometrial cancer. Int J Gynecol Cancer. 2012;22(9):1509-16.

  [4]. Yu S, Wang X, Ng CF, et al. ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Res. 2007;67(10):4904-14.

  [5]. Donna D. Yu, Barry Marc Forman. Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorganic & Medicinal Chemistry Letters. 2005,15(5): 1311-1313.

DY131物理化学性质

• 密度: 1.1±0.1 g/cm3
• 分子式: C₁₈H₂₁N₃O₂
• 分子量: 311.378
• 精确质量: 311.163391
• PSA: 64.93000
• LogP: 3.17
• InChIKey: WLKOCYWYAWBGKY-UYRXBGFRSA-N
• SMILES: CCN(CC)c1ccc(C=NNC(=O)c2ccc(O)cc2)cc1
• 折射率: 1.574
• 储存条件: 2-8°C

DY131安全信息

• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26-36
• 海关编码: 2928000090

DY131海关

• 海关编码: 2928000090
• 中文概述: 2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

DY131英文别名

• Benzoic acid, 4-hydroxy-, 2-[(1E)-[4-(diethylamino)phenyl]methylene]hydrazide
• N'-{(E)-[4-(diethylamino)phenyl]methylidene}-4-hydroxybenzohydrazide
• N'-{(E)-[4-(Diethylamino)phenyl]methylene}-4-hydroxybenzohydrazide
• Benzoic acid, 4-hydroxy-, [[4-(diethylamino)phenyl]methylene]hydrazide (9CI)
• N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine
• GSK 9089