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DY131

DY131用途

DY131(GSK 9089)是ERRβ和ERRγ选择性激动剂,对ERRα,ERα和ERβ的活性极低。

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DY131名称

[ CAS 号 ]:
95167-41-2

[ 中文名 ]:
DY131

[ 英文名 ]:
DY131

[英文别名 ]:

GSK 9089

DY131生物活性

[ 描述 ]:

DY131(GSK 9089)是ERRβ和ERRγ选择性激动剂,对ERRα,ERα和ERβ的活性极低。

[ 相关类别 ]:

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 癌症

[参考文献]

[1]. Wang Y, Arvanites AC, Davidow L,et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation . ACS Chem Biol. 2012,15;7(6):1040-8.

[2]. Kumar P, Mendelson CR. Estrogen-related receptor gamma (ERRgamma) mediates oxygen-dependent induction of aromatase (CYP19) gene expression during human trophoblast differentiation. Mol Endocrinol. 2011;25(9):1513-26.

[3]. Yamamoto T, Mori T, Sawada M, et al. Estrogen-related receptor-γ regulates estrogen receptor-α responsiveness in uterine endometrial cancer. Int J Gynecol Cancer. 2012;22(9):1509-16.

[4]. Yu S, Wang X, Ng CF, et al. ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Res. 2007;67(10):4904-14.

[5]. Donna D. Yu, Barry Marc Forman. Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorganic & Medicinal Chemistry Letters. 2005,15(5): 1311-1313.

[相关活性小分子]

DY131物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 分子式 ]:
C₁₈H₂₁N₃O₂

[ 分子量 ]:
311.378

[ 精确质量 ]:
311.163391

[ PSA ]:
64.93000

[ LogP ]:
3.17

[ 折射率 ]:
1.574

[ 储存条件 ]:
2-8°C

DY131安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 海关编码 ]:
2928000090

DY131合成路线

详细合成路线

DY131上下游产品

DY131上游产品

DY131下游产品

DY131海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%