托吡酯

• 常用名: 托吡酯
• 英文名: Topiramate
• CAS号: 97240-79-4
• 分子量: 339.362
• 密度: 1.3±0.1 g/cm3
• 沸点: 438.7±55.0 °C at 760 mmHg
• 分子式: C₁₂H₂₁NO₈S
• 熔点: 125ºC
• 闪点: 219.1±31.5 °C
• 符号: GHS02, GHS06, GHS08
• 信号词: Danger

托吡酯用途

Topiramate是镇痉化合物,能拮抗GluR5受体,还可作为GABA受体介导的电流阳性变构调节剂。

托吡酯名称

• 中文名: 托吡酯
• 英文名: topiramate
• 中文别名: 2,3:4,5-双-0-(1-甲基亚乙基)-Β-吡喃果糖氨基磺酸酯 | 2,3,4,5-双-O-(1-甲基亚乙基)-Β-D-吡喃果糖氨基磺酸酯 | 托佩马特 | 2,3,4,5-双-o-(1-甲基亚乙基)-β-d-吡喃果糖氨基磺酸酯 | 妥泰,2,3:4,5-双-0-(1-甲基亚乙基)-β-吡喃果糖氨基磺酸酯 | 妥吡酯

托吡酯生物活性

• 描述: Topiramate是镇痉化合物,能拮抗GluR5受体,还可作为GABA受体介导的电流阳性变构调节剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67(15):2231-56.

  [2]. Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115(1):53-7.

  [3]. Ormrod D, et al. Topiramate: a review of its use in childhood epilepsy. Paediatr Drugs. 2001;3(4):293-319.

托吡酯物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 438.7±55.0 °C at 760 mmHg
• 熔点: 125ºC
• 分子式: C₁₂H₂₁NO₈S
• 分子量: 339.362
• 闪点: 219.1±31.5 °C
• 精确质量: 339.098785
• PSA: 123.92000
• LogP: 2.97
• InChIKey: KJADKKWYZYXHBB-XBWDGYHZSA-N
• SMILES: CC1(C)OC2COC3(COS(N)(=O)=O)OC(C)(C)OC3C2O1
• 外观性状: 白色至灰白色结晶粉末
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.497
• 储存条件: 0-10°C;避免加热
• 水溶解性: 可溶于：甲醇

托吡酯MSDS

托吡酯MSDS英文版

托吡酯毒性和生态

托吡酯安全信息

• 符号: GHS02, GHS06, GHS08
• 信号词: Danger
• 危害声明: H225-H301 + H311 + H331-H370
• 警示性声明: P210-P260-P280-P301 + P310-P311
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-36
• 危险品运输编码: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK德国: 3
• RTECS号: LS7083000

托吡酯靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Inhibition of recombinant human CA7 incubated for 15 mins by phenol red dye based sto... 来源：ChEMBL 靶标：Carbonic anhydrase 7 External Id：CHEMBL4813795

实验名称：Inhibition of full length human CA9 incubated for 15 mins by phenol red dye based sto... 来源：ChEMBL 靶标：Carbonic anhydrase 9 External Id：CHEMBL4813796

实验名称：Increase the activity of the Burkholderia fixLJ 2-component system 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Burkholderia multivorans External Id：HMS1625

实验名称：Inhibition of Vibrio cholerae alpha-carbonic anhydrase using CO2 as substrate preincu... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3761240

实验名称：Inhibition of Vibrio cholerae beta-carbonic anhydrase using CO2 as substrate preincub... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3760464

实验名称：Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mi... 来源：ChEMBL 靶标：Carbonic anhydrase 1 External Id：CHEMBL3761242

实验名称：Selectivity ratio of Ki for human recombinant carbonic anhydrase 2 to Ki for human re... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1788075

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托吡酯英文别名

• Topamax Sprinkle
• 2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulfamate
• Topiramate
• Topimax
• Tipiramato [Spanish]
• Epitomax
• McN-4853
• topiramatum [Latin]
• topiramatum
• Tipiramate [French]
• [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methyl sulfamate
• Tipiramate
• [(3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
• RWJ 17021-000
• Topamax
• Topomax
• Topiramato [INN-Spanish]