托吡酯
托吡酯结构式
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常用名 | 托吡酯 | 英文名 | Topiramate |
|---|---|---|---|---|
| CAS号 | 97240-79-4 | 分子量 | 339.362 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 438.7±55.0 °C at 760 mmHg | |
| 分子式 | C12H21NO8S | 熔点 | 125ºC | |
| MSDS | 中文版 美版 | 闪点 | 219.1±31.5 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.
Nature 457(7231) , 910-4, (2009) Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion an... |
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Kainic Acid-Induced Golgi Complex Fragmentation/Dispersal Shifts the Proteolysis of Reelin in Primary Rat Neuronal Cells: An In Vitro Model of Early Stage Epilepsy.
Mol. Neurobiol. , (2015) The endoplasmic reticulum-lysosome-Golgi network plays an important role in Reelin glycosylation and its proteolytic processing. Golgi complex fragmentation is associated with the separation of Reelin from this network. Kainic acid (KA) is an excitotoxic agen... |
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Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis.
JAMA 311(18) , 1889-900, (2014) Alcohol use disorders cause substantial morbidity and early mortality yet remain greatly undertreated. Medications are considerably underused.To conduct a systematic review and meta-analysis of the benefits and harms of medications (US FDA-approved and others... |
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Evaluation of the matrix effect of different sample matrices for 33 pharmaceuticals by post-column infusion.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1000 , 84-94, (2015) Matrix effects that occur during quantitative measurement by liquid chromatography mass spectrometry specifically when using electrospray ionization are a widely recognized phenomenon. Sample matrix compounds affect the ionization process of the target analyt... |
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Phentermine/topiramate for the treatment of obesity.
Ann. Pharmacother. 47(3) , 340-9, (2013) To review the pharmacology, efficacy, and safety of phentermine/topiramate (PHEN/TPM) in the management of obese patients.MEDLINE (1966-July 2012) was searched using the terms weight loss, obesity, phentermine and topiramate, phentermine, topiramate, Qnexa, Q... |
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Obesity drug therapy.
Minerva Endocrinol. 38(3) , 245-54, (2013) Obesity is a chronic disease, and it requires chronic therapy. Hypertension, dyslipidemia, diabetes and cardiovascular diseases are leading causes of mortality in the modern world. All of them are strongly linked to obesity. While treating obesity, those cond... |
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The new weight-loss drugs, lorcaserin and phentermine-topiramate: slim pickings?
JAMA Intern. Med. 174(4) , 615-9, (2014) In 2012, the US Food and Drug Administration approved 2 drugs for long-term weight loss: lorcaserin hydrochloride (Belviq; Eisai Inc) and phentermine-topiramate (Qysmia; Vivus Inc). The approvals were based on 1-year trials showing that on top of recommendati... |
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Weight-reducing side effects of the antiepileptic agents topiramate and zonisamide.
Handbook of Experimental Pharmacology (209) , 433-66, (2012) Drug-induced weight alteration can be a serious side effect that applies to several therapeutic agents and must be referred to in the respective approved labeling texts. The side effect may become health threatening in case of significant weight change in eit... |
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Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy.
Neurology 52(3) , 473-8, (1999) To measure the effects of topiramate on brain gamma-aminobutyric acid (GABA) in patients with epilepsy.Topiramate is a new antiepileptic medication with multiple putative mechanisms of action. In a recent meta-analysis of the newer antiepileptic drugs, topira... |
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New obesity agents: lorcaserin and phentermine/topiramate.
Ann. Pharmacother. 47(7-8) , 1007-16, (2013) To evaluate the evidence for lorcaserin and phentermine/topiramate in the treatment of obesity.Literature was accessed through PubMed (June 1975-March 2013) using the search terms lorcaserin, phentermine, topiramate, or phenter mine/topiramate. Additionally, ... |