硝基卡拉米芬盐酸盐

• 常用名: 硝基卡拉米芬盐酸盐
• 英文名: Nitrocaramiphen hydrochloride
• CAS号: 98636-73-8
• 分子量: 370.87
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₂₇ClN₂O₄
• 熔点: N/A
• 闪点: N/A

硝基卡拉米芬盐酸盐用途

盐酸硝基卡拉米芬是一种选择性M1受体拮抗剂(Ki:5.5nM)。盐酸硝基卡拉米芬抑制肌肉纤维中毒蕈碱的超极化作用[1][2][3]。

硝基卡拉米芬盐酸盐名称

• 中文名: 硝基卡拉米芬盐酸盐
• 英文名: Nitrocaramiphen hydrochloride

硝基卡拉米芬盐酸盐生物活性

• 描述: 盐酸硝基卡拉米芬是一种选择性M1受体拮抗剂(Ki:5.5nM)。盐酸硝基卡拉米芬抑制肌肉纤维中毒蕈碱的超极化作用[1][2][3]。
• 相关类别:
  信号通路 >> 神经信号通路 >> mAChR
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  研究领域 >> 神经疾病
• 靶点实验:

  Ki: 5.5 nM (M1 receptor)[2]

• 参考文献:

  [1]. Hussain RI, et al. Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. Br J Pharmacol. 2009 Feb;156(4):575-86.

  [2]. Hudkins RL, et al. Caramiphen, iodocaramiphen and nitrocaramiphen are potent, competitive, muscarinic M1 receptor-selective agents. Eur J Pharmacol. 1993 Feb 16;231(3):485-8.

  [3]. Naumenko NV, et al. [Pharmacological parameters of muscarinic cholinoreceptors in skeletal muscles]. Ross Fiziol Zh Im I M Sechenova. 2002 May;88(5):619-26.

硝基卡拉米芬盐酸盐物理化学性质

• 分子式: C₁₈H₂₇ClN₂O₄
• 分子量: 370.87
• 精确质量: 370.16600
• PSA: 75.36000
• LogP: 4.61680
• InChIKey: XWQWACGTGFICFO-UHFFFAOYSA-N
• SMILES: CCN(CC)CCOC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCCC1.Cl
• 储存条件: -20°C

硝基卡拉米芬盐酸盐靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Displacement of [3H]pirenzepine from muscarinic acetylcholine receptor M1 in rat cort... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1 External Id：CHEMBL745663

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

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硝基卡拉米芬盐酸盐英文别名

• [Sar9,Met(O2)11]-Substance P