Jervine
Jervine structure
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Common Name | Jervine | ||
|---|---|---|---|---|
| CAS Number | 469-59-0 | Molecular Weight | 425.603 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 592.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C27H39NO3 | Melting Point | 242- 244ºC | |
| MSDS | Chinese USA | Flash Point | 311.8±30.1 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Development of an enzyme-linked immunosorbent assay for the veratrum plant teratogens: cyclopamine and jervine.
J. Agric. Food Chem. 51(3) , 582-6, (2003) Veratrum californicum was responsible for large losses of sheep grazing high mountain ranges in central Idaho in the 1950s. Veratrum induces various birth defects including the cyclopic-type craniofacial defect (monkey-faced lambs) that is specifically induce... |
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Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect.
Exp. Cell Res. 319(7) , 1043-53, (2013) Erythroleukemia is generally associated with a very poor response and survival to current available therapeutic agents. Cyclooxygenase-2 (COX-2) has been described to play a crucial role in the proliferation and differentiation of leukemia cells, this enzyme ... |
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Effects of Veratrum nigrum alkaloids on central catecholaminergic neurons of renal hypertensive rats.
Acta Pharmacol. Sin. 21(1) , 23-8, (2000) To study the central hypotensive mechanism of Veratrum nigrum L var ussurience Nakai alkaloids (VnA) in renal hypertensive rats(RHR).The quantitative method of immunocytochemistry (ICC) was used to observe and detect the effect of VnA (30 micrograms.kg-1, i.v... |
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Transformation of jervine by Cunninghamella elegans ATCC 9245.
Phytochemistry 55(1) , 19-22, (2000) Preparative-scale fermentation of the known C-nor-D-homosteroidal jerveratrum alkaloid jervine with Cunninghamella elegans (ATCC 9245) has resulted in the isolation of (-)-jervinone as the major metabolite. In addition, C. elegans ATCC 9245 was able to epimer... |
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Ingestion of false hellebore plants can cross-react with a digoxin clinical chemistry assay.
Clin. Toxicol. (Phila.) 48(5) , 435-42, (2010) We report a case of digoxin-like toxicity because of ingestion of foraged plants. This patient presented with nausea, vomiting, bradycardia, and hypotension after ingesting Veratrum viride (false hellebore). The patient's serum specimen demonstrated a positiv... |
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Embryonic tongue morphogenesis in an organ culture model of mouse mandibular arches: blocking Sonic hedgehog signaling leads to microglossia.
In Vitro Cell. Dev. Biol. Anim. 52 , 89-99, (2016) Mouse tongue development is initiated with the formation of lateral lingual swellings just before fusion between the mediodorsal surfaces of the mandibular arches at around embryonic day 11.0. Here, we investigated the role of Sonic hedgehog (Shh) signaling i... |
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Specific craniofacial defects induced by jervine in the cultured rat embryo.
Teratog. Carcinog. Mutagen. 3(2) , 111-21, (1983) The Veratrum-derived steroidal alkaloid, jervine, induces cyclopia and limb malformations in sheep, and various other craniofacial malformations in several other mammalian and avian species. In the present study, the question whether jervine acts directly or ... |
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[The structure and absolute configuration of vertaline B isolated from Veratrum taliense Lose. f].
Yao Xue Xue Bao 23(8) , 584-7, (1988)
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[Chemical studies on alkaloids from Veratrum nigrum].
Zhong Yao Tong Bao 12(1) , 34-5, (1987)
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[Determination of jervine and veratramine in Veratrum plants using high performance liquid chromatography coupled with evaporative light scattering detection].
Se Pu 26(1) , 56-9, (2008) A method of reversed-phase high performance liquid chromatography (HPLC) coupled with evaporative light scattering detection (ELSD) was developed for the determination of jervine and veratramine in veratrum plants. The extraction method of total active alkalo... |