N,N′-diisopropylcarbodiimide

N,N′-diisopropylcarbodiimide Structure
N,N′-diisopropylcarbodiimide structure
Common Name N,N′-diisopropylcarbodiimide
CAS Number 693-13-0 Molecular Weight 126.200
Density 0.8±0.1 g/cm3 Boiling Point 146.5±9.0 °C at 760 mmHg
Molecular Formula C7H14N2 Melting Point 210-2120C (dec)
MSDS Chinese USA Flash Point 33.9±0.0 °C
Symbol GHS05 GHS06 GHS08
GHS05, GHS06, GHS08
Signal Word Danger

LRRK1-phosphorylated CLIP-170 regulates EGFR trafficking by recruiting p150Glued to microtubule plus ends.

J. Cell Sci. 128(2) , 385-96, (2015)

The binding of ligand to epidermal growth factor receptor (EGFR) causes the receptor to become activated and stimulates the endocytosis of EGFR. Early endosomes containing activated EGFR migrate along microtubules as they mature into late endosomes. We have r...

DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity.

J. Exp. Med. 211(13) , 2549-66, (2014)

DOCK8 mutations result in an inherited combined immunodeficiency characterized by increased susceptibility to skin and other infections. We show that when DOCK8-deficient T and NK cells migrate through confined spaces, they develop cell shape and nuclear defo...

Incorporation of electrochemical advanced oxidation processes in a multistage treatment system for sanitary landfill leachate.

Water Res. 81 , 375-87, (2015)

The current study has proved the technical feasibility of including electrochemical advanced oxidation processes (EAOPs) in a multistage strategy for the remediation of a sanitary landfill leachate that embraced: (i) first biological treatment to remove the b...

NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease.

Hum. Mol. Genet. 24 , 3058-81, (2015)

Disarrangement in functions and quality control of mitochondria at synapses are early events in Alzheimer's disease (AD) pathobiology. We reported that a 20-22 kDa NH2-tau fragment mapping between 26 and 230 amino acids of the longest human tau isoform (aka N...

Optimized inorganic carbon regime for enhanced growth and lipid accumulation in Chlorella vulgaris.

Biotechnol. Biofuels 8 , 82, (2015)

Large-scale algal biofuel production has been limited, among other factors, by the availability of inorganic carbon in the culture medium at concentrations higher than achievable with atmospheric CO2. Life cycle analyses have concluded that costs associated w...

Reduction of established antibody responses against botulinum neurotoxin A by synthetic monomethoxypolyethylene glycol peptide conjugates.

J. Neuroimmunol. 272(1-2) , 29-34, (2014)

In cervical dystonia, injection of botulinum neurotoxin (BoNT) A or B into affected neck muscle reduces symptoms but may elicit anti-toxin antibodies (Abs) that block responsiveness to treatment. Previously, we localized the BoNT/A and BoNT/B sites that bind ...

Compact and blinking-suppressed quantum dots for single-particle tracking in live cells.

J. Phys. Chem. B 118(49) , 14140-7, (2014)

Quantum dots (QDs) offer distinct advantages over organic dyes and fluorescent proteins for biological imaging applications because of their brightness, photostability, and tunability. However, a major limitation is that single QDs emit fluorescent light in a...

Peptide dimethylation: fragmentation control via distancing the dimethylamino group.

J. Am. Soc. Mass Spectrom. 25(10) , 1694-704, (2014)

Direct reductive methylation of peptides is a common method for quantitative proteomics. It is an active derivatization technique; with participation of the dimethylamino group, the derivatized peptides preferentially release intense a1 ions. The advantageous...

Stabilization of resveratrol in blood circulation by conjugation to mPEG and mPEG-PLA polymers: investigation of conjugate linker and polymer composition on stability, metabolism, antioxidant activity and pharmacokinetic profile.

PLoS ONE 10(3) , e0118824, (2015)

Resveratrol is naturally occurring phytochemical with diverse biological activities such as chemoprevention, anti-inflammatory, anti-cancer, anti-oxidant. But undergoes rapid metabolism in the body (half life 0.13h). Hence Polymer conjugation utilizing differ...

Fabric phase sorptive extraction: a new sorptive microextraction technique for the determination of non-steroidal anti-inflammatory drugs from environmental water samples.

Anal. Chim. Acta 865 , 22-30, (2015)

Fabric phase sorptive extraction (FPSE) is a new, yet very promising member of the sorbent-based sorptive microextraction family. It has simultaneously improved both the extraction sensitivity and the speed of the extraction by incorporating high volume of so...