2H-1-Benzopyran-4-aceticacid, 7-hydroxy-2-oxo-
2H-1-Benzopyran-4-aceticacid, 7-hydroxy-2-oxo- structure
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Common Name | 2H-1-Benzopyran-4-aceticacid, 7-hydroxy-2-oxo- | ||
|---|---|---|---|---|
| CAS Number | 6950-82-9 | Molecular Weight | 220.17800 | |
| Density | 1.511 g/cm3 | Boiling Point | 523.5ºC at 760 mmHg | |
| Molecular Formula | C11H8O5 | Melting Point | 212 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 214.5ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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DNA-Linked Enzyme-Coupled Assay for Probing Glucosyltransferase Specificity.
ACS Synth. Biol. 4 , 833-41, (2015) Traditional enzyme characterization methods are low-throughput and therefore limit engineering efforts in synthetic biology and biotechnology. Here, we propose a DNA-linked enzyme-coupled assay (DLEnCA) to monitor enzyme reactions in a high-throughput manner.... |
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Towards a Second Generation of Ionic Liquid Matrices (ILMs) for MALDI-MS of Peptides, Proteins, and Carbohydrates
J. Am. Soc. Mass Spectrom. 20 , 1790-1800, (2009) Second generation ionic liquid matrices are developed, examined, and tested. They have shown a wide mass detection range (<1000 Da to >270,000 Da) for proteins and peptides with greater S/N ratios than solid matrices. These ionic liquid matrices also exhibit ... |
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Design and synthesis of substrates for newborn screening of Maroteaux-Lamy and Morquio A syndromes.
Bioorg. Med. Chem. Lett. 20(20) , 5994-6, (2010) In continued efforts to develop enzymatic assays for lysosomal storage diseases appropriate for newborn screening laboratories we have synthesized novel and specific enzyme substrates for Maroteaux-Lamy (MPS VI) and Morquio A (MPS IVA) diseases. The sulfated ... |
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Stopped-flow kinetic analysis of long-chain fatty acid dissociation from bovine serum albumin.
Biochem. J. 363(Pt 3) , 809-15, (2002) The kinetics of the interaction of long-chain fatty acids (referred to as fatty acids) with albumin is critical to understanding the role of albumin in fatty acid transport. In this study we have determined the kinetics of fatty acid dissociation from BSA and... |
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Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution.
Nat. Chem. Biol. 3 , 657-62, (2007) Natural products, many of which are decorated with essential sugar residues, continue to serve as a key platform for drug development. Adding or changing sugars attached to such natural products can improve the parent compound's pharmacological properties, sp... |
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Covalent complexes between serum albumin and 7-hydroxycoumarin-4-acetic acid: synthesis and applications in the spectrophotometric detection of long-chain fatty acids.
Biochim. Biophys. Acta 1304(1) , 43-55, (1996) Using a hydrophobic 8-aminooctanoic acid cross-linker, the pH-indicator dye 7-hydroxycoumarin-4-acetic acid (7-HCA) is covalently bound to bovine serum albumin (BSA) at the positions of reactive amino groups. A highly stable and water-soluble complex (BSA-HCA... |
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Bovine serum albumin-(7-hydroxycoumarin-4-acetic acid) complex: applications to the fluorometric measurement of fatty acid concentrations.
Anal. Biochem. 267(2) , 366-72, (1999) A covalent complex between bovine serum albumin and 7-hydroxycoumarin-4-acetic acid (BSA-HCA) shows a strong fluorescence band at lambdamax = 450 nm upon excitation at 375 nm. Quenching of the fluorescence emission accompanies the association of fatty acids (... |
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Continuous recording of long-chain acyl-coenzyme a synthetase activity using fluorescently labeled bovine serum albumin.
Anal. Biochem. 295(1) , 38-44, (2001) The fluorescence-based long-chain fatty acid probe BSA-HCA (bovine serum albumin labeled with 7-hydroxycoumarin-4-acetic acid) is shown to respond to binding of long-chain acyl-CoA thioesters by quenching of the 450 nm fluorescence emission. As determined by ... |
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6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2.
Bioorg. Med. Chem. Lett. 20 , 5630-3, (2010) We report the structure-activity relationship of a series of coumarins as aldose reductase 2 (ALR2) inhibitors and their suppressive effect on the accumulation of galactitol in the rat lens. We evaluated their ALR2 selectivity profile against sorbitol dehydro... |