5-Chloro-2-fluorobenzonitrile

5-Chloro-2-fluorobenzonitrile Structure
5-Chloro-2-fluorobenzonitrile structure
Common Name 5-Chloro-2-fluorobenzonitrile
CAS Number 57381-34-7 Molecular Weight 155.557
Density 1.3±0.1 g/cm3 Boiling Point 202.5±20.0 °C at 760 mmHg
Molecular Formula C7H3ClFN Melting Point 67-70°C
MSDS Chinese USA Flash Point 76.3±21.8 °C
Symbol GHS07
GHS07
Signal Word Warning

Microwave-assisted synthesis of 3-aminobenzo[b]thiophene scaffolds for the preparation of kinase inhibitors.

.PubMed ID

Microwave irradiation of 2-halobenzonitriles and methyl thioglycolate in the presence of triethylamine in DMSO at 130 °C provides rapid access to 3-aminobenzo[b]thiophenes in 58-96% yield. This transformation has been applied in the synthesis of the thieno[2,...

Analysis of Small Molecule X-Ray Crystal Structures: Chemical Crystallography with Undergraduate Students in a Teaching Laboratory. Aldeborgh H, et al.

J. Chem. Crystallogr. 44(2) , 70-81, (2014)