N6-(2-Phenylethyl)adenosine
N6-(2-Phenylethyl)adenosine structure
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Common Name | N6-(2-Phenylethyl)adenosine | ||
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| CAS Number | 20125-39-7 | Molecular Weight | 371.39000 | |
| Density | 1.57g/cm3 | Boiling Point | 723.5ºC at 760 mmHg | |
| Molecular Formula | C18H21N5O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 391.3ºC | |
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Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin.
Nucleic Acids Res. 39 , 4373-86, (2011) The carbon catabolite repressor protein 4 (Ccr4)-Negative on TATA (Not) complex controls gene expression at two levels. In the nucleus, it regulates the basal transcription machinery, nuclear receptor-mediated transcription and histone modifications. In the c... |
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Exploring distal regions of the A3 adenosine receptor binding site: sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands.
Bioorg. Med. Chem. 12 , 2021-2034, (2004) We synthesized phenyl ring-substituted analogues of N(6)-(1S,2R)-(2-phenyl-1-cyclopropyl)adenosine, which is highly potent in binding to the human A(3)AR with a Ki value of 0.63 nM. The effects of these structural changes on affinity at human and rat adenosin... |
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Effects of adenosine receptor agonists and antagonists on audiogenic seizure-sensible DBA/2 mice.
Eur. J. Pharmacol. 371 , 137-145, (1999) We have studied the effects of selective and non-selective adenosine receptor agonists and antagonists in audiogenic-seizure-sensitive DBA/2 mice, an animal model of generalized reflex epilepsy. With the exception of the adenosine A3 receptor agonist, N6-(3-i... |
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Species-dependent hemodynamic effects of adenosine A3-receptor agonists IB-MECA and Cl-IB-MECA.
Am. J. Physiol. 276 , H2076-2084, (1999) The purpose of this study was to compare the hemodynamic effects of the adenosine A3-receptor agonists N6-(3-iodobenzyl)-9-[5-(methylcarbamoyl)-beta-D-ribofuranosyl]aden ine (IB-MECA) and 2-chloro-N6-(3-iodobenzyl)-9-[5-(methylcarbamoyl)-beta-D-ribofu ranosy ... |
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Mechanism of G551D-CFTR (cystic fibrosis transmembrane conductance regulator) potentiation by a high affinity ATP analog.
J. Biol. Chem. 283 , 5364-5369, (2008) Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel gated by ATP binding and hydrolysis at its nucleotide binding domains (NBD). The NBDs dimerize in a head-to-tail configuration, forming two ATP binding pockets (ABP) with the ATP... |